Cutting-Edge Imaging Techniques for GPCR Signaling

Precise control of cellular communication and signaling is crucial for every physiological system, with G protein-coupled receptors (GPCRs, the largest family of signaling receptors) playing a central role as essential molecular sensors of a cell’s environment. 

Because of their diverse physiological and pathophysiological roles, GPCRs are also major drug targets. 

Our understanding of GPCR signaling has evolved from single receptors at the cell surface activating specific heterotrimeric G protein pathways, to an increasingly complex receptor signaling system. 

However, how such complexity in GPCR signaling is translated to specific cellular and physiological responses is still unclear. 

Understanding these mechanisms is an area of precedence due to the intense interest in identifying GPCR modulators with high specificity in action. 

In this webinar, we discuss some of our endeavors to uncover these molecular mechanisms through a wide range of imaging applications to study GPCRs across scales from single molecules to identification of new subcellular signal platforms and the downstream cellular significance of receptor location to fundamental cellular functions. 

This session is relevant to scientists in cell biology, pharmacology, endocrine, and metabolism.