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Biowissenschaften

Hier können Sie Ihr Wissen, Ihre Forschungsfähigkeiten und Ihre praktischen Anwendungen der Mikroskopie in verschiedenen wissenschaftlichen Bereichen erweitern. Erfahren Sie, wie Sie präzise Visualisierung, Bildinterpretation und Forschungsfortschritte erzielen können. Hier finden Sie aufschlussreiche Informationen über fortgeschrittene Mikroskopie, Bildgebungsverfahren, Probenvorbereitung und Bildanalyse. Zu den behandelten Themen gehören Zellbiologie, Neurowissenschaften und Krebsforschung mit Schwerpunkt auf modernsten Anwendungen und Innovationen.

Dronpa chromophore

Photoactivatable, Photoconvertible, and Photoswitchable Fluorescent Proteins

Fluorescent proteins (FPs) such as GFP, YFP or DsRed are powerful tools to visualize cellular components in living cells. Nevertheless, there are circumstances when classical FPs reach their limits.…

Airy-Muster in der Fokusebene.

Was macht das Pinhole im konfokalen Mikroskop?

Diese kurze einführende Schrift soll die Bedeutung des Pinholes erläutern und ist für Leser gedacht, die nicht allzu viel Zeit mit der Theorie und den Details der konfokalen Mikroskopie verbringen…

Comparison when observing a rodent model organism with a Greenough versus CMO (common main objective) stereo microscope for a task like surgery.

Rodent and Small-Animal Surgery

Learn how you can perform rodent (mouse, rat, hamster) and small-animal surgery efficiently with a microscope for developmental biology and medical research applications by reading this article.

Left: Tissue cells marked with an immunolabel (FITC) illuminated with wide-band UV excitation. Note the tissue structure with blue autofluorescence. Right: Same tissue and same immunostaining with FITC label illuminated with epi-illumination using narrow-band blue (490 nm) light. Note the increased image contrast (Ploem, 1967)

Milestones in Incident Light Fluorescence Microscopy

Since the middle of the last century, fluorescence microscopy developed into a bio scientific tool with one of the biggest impacts on our understanding of life. Watching cells and proteins with the…

HeLa cells stimulated with LPS. Image has been subjected to deconvolution.

Chronic Inflammation Under the Microscope

In the course of chronic inflammation certain body areas are recurrently inflamed. This goes along with many human diseases. With the help of widefield light microscopy, the underlying processes can…

Gene editing with Cas9

Gene Editing with CRISPR/Cas9 - Breakthrough in Genome Engineering

The CRISPR/Cas9 system is one of several different bacterial systems for defense against viral attacks. It consists of two main components. One is a small piece of RNA which binds to the viral target…

Transgenic zebrafish larva where fluorescent proteins label the heart muscle blue, blood and blood vessels red, and all circulatory system cells green. Image recorded with a M205 FA microscope.

Imaging and Analyzing Zebrafish, Medaka, and Xenopus

Discover how to image and analyze zebrafish, medaka, and Xenopus frog model organisms efficiently with a microscope for developmental biology applications from this article.

Bacteria Protocol - Critical Point Drying of E. coli for SEM

Application Note for Leica EM CPD300 - Critical point drying of E. coli with subsequent platinum / palladium coating and SEM analysis. Sample was inserted into a filter disc (Pore size: 16 - 40 μm)…

Fluorescence stereo microscope image of anesthetized Mediterranean fruit flies recorded with a M205 stereo microscope.

Investigating Fruit Flies (Drosophila melanogaster)

Learn how to image and investigate Drosophila fruit fly model organisms efficiently with a microscope for developmental biology applications from this article.