Leica Microsystems
Leica Microsystems ist ein weltweit führender Hersteller von Mikroskopen und wissenschaftlichen Instrumenten. Im 19. Jahrhundert als Familienunternehmen gegründet, war die Geschichte des Unternehmens auf dem Weg zum Weltkonzern von beispielloser Innovation geprägt.
Die traditionell enge Zusammenarbeit mit der Wissenschaft ist der Schlüssel zur Innovationstradition von Leica Microsystems, die auf die Ideen der Anwender zurückgreift und auf deren Bedürfnisse zugeschnittene Lösungen schafft. Auf globaler Ebene ist Leica Microsystems in drei Divisionen gegliedert, die alle zu den führenden Anbietern in ihrem jeweiligen Bereich gehören: Life Science, Industrie und Medizin.
Das Unternehmen ist in über 100 Ländern mit 6 Produktionsstandorten in 5 Ländern, Vertriebs- und Serviceorganisationen in 20 Ländern und einem internationalen Händlernetz vertreten. Der Hauptsitz des Unternehmens liegt in Wetzlar, Deutschland.
How to Automatically Obtain Fluorescent Cells of Interest in a Block-face
Block-face created by automatic trimming under fluorescence.
Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the…
Deep Visual Proteomics Provides Precise Spatial Proteomic Information
Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance…
What is Empty Magnification and How can Users Avoid it
The phenomenon of “empty magnification”, which can occur while using an optical, light, or digital microscope, and how it can be avoided is explained in this article. The performance of an optical…
How to Study Gene Regulatory Networks in Embryonic Development
Join Dr. Andrea Boni by attending this on-demand webinar to explore how light-sheet microscopy revolutionizes developmental biology. This advanced imaging technique allows for high-speed, volumetric…
Spatial Analysis of Neuroimmune Interactions in Alzheimer’s Disease
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by neurofibrillary tangles, β-amyloid plaques, and neuroinflammation. These dysfunctions trigger or are exacerbated by…
Das Prinzip der Polarisationsmikroskopie
Die Polarisationsmikroskopie wird in den Material- und Geowissenschaften routinemäßig eingesetzt, um Materialien und Mineralien anhand ihrer charakteristischen Brechungseigenschaften und Farben zu…
A Guide to Spatial Biology
What is spatial biology, and how can researchers leverage its tools to meet the growing demands of biological questions in the post-omics era? This article provides a brief overview of spatial biology…
Cutting-Edge Imaging Techniques for GPCR Signaling
With this webinar on-demand enhance your pharmacological research with our webinar on GPCR signaling and explore cutting-edge imaging techniques that aim to understand how GPCR signaling translates…
Mikrobielle Welten erforschen: Räumliche Interaktionen in 3D Lebensmittelmatrizen
Das Micalis Institute ist eine gemeinsame Forschungseinheit in Zusammenarbeit mit INRAE, AgroParisTech und der Université Paris-Saclay. Seine Mission ist es, innovative Forschung im Bereich der…
Molecular Biology Analysis facilitated with Laser Microdissection (LMD)
Extracting biomolecules, proteins, nucleic acids, lipids, and chromosomes, as well as extracting and manipulating cells and tissues with laser microdissection (LMD) enables insights to be gained into…
Probing Human Alzheimer's Cortical Section using Spatial Multiplexing
Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by the progressive decline of cognitive function. Spatial profiling of AD brain may reveal cellular…
Spatial Metabolomics: Exploring Tumor Complexity and Therapeutic Insights
In cancer research, it is vital to understand the interaction between tumor cells and their microenvironment, as the tumor microenvironment influences tumor progression significantly. Spatial…
Advancing Uterine Regenerative Therapies with Endometrial Organoids
Prof. Kang's group investigates important factors that determine the uterine microenvironment in which embryo insertion and pregnancy are successfully maintained. They are working to develop new…
Lipidomics Analysis of Sparse Cells based on Laser Microdissection
Delve into cellular intricacies with high-coverage targeted lipidomics analysis of sparse cells. This advanced method, integrating Laser Microdissection (LMD) and Liquid Chromatography-Mass…
Rapidly Visualizing Magnetic Domains in Steel with Kerr Microscopy
The rotation of polarized light after interaction with magnetic domains in a material, known as the Kerr effect, enables the investigation of magnetized samples with Kerr microscopy. It allows rapid…
Leveraging AI for Efficient Analysis of Cell Transfection
This article explores the pivotal role of artificial intelligence (AI) in optimizing transfection efficiency measurements within the context of 2D cell culture studies. Precise and reliable…
Precision and Efficiency with AI-Enhanced Cell Counting
This article describes the use of artificial intelligence (AI) for precise and efficient cell counting. Accurate cell counting is important for research with 2D cell cultures, e.g., cellular dynamics,…
AI Confluency Analysis for Enhanced Precision in 2D Cell Culture
This article explains how efficient, precise confluency assessment of 2D cell culture can be done with artificial intelligence (AI). Assessing confluency, the percentage of surface area covered,…
Empowering Spatial Biology with Open Multiplexing and Cell DIVE
Spatial biology and multiplexed imaging workflows have become important in immuno-oncology research. Many researchers struggle with study efficiency, even with effective tools and protocols. Here, we…
Neuron Isolation in Spatial Context with Laser Microdissection (LMD)
After Alzheimer’s disease, Parkinson’s is the second most common progressive neurodegenerative disease. Before the first symptoms manifest, up to 70% of dopamine-releasing neurons in the mid-brain…
How did Laser Microdissection enable Pioneering Neuroscience Research?
Dr. Marta Paterlini, a Senior Scientist at the Karolinska Institute, shares her experience of using laser microdissection (LMD) in groundbreaking research into adult human neurogenesis and offers…
6-Inch Wafer Inspection Microscope for Reliably Observing Small Height Differences
A 6-inch wafer inspection microscope with automated and reproducible DIC (differential interference contrast) imaging, no matter the skill level of users, is described in this article. Manufacturing…
Visualizing Photoresist Residue and Organic Contamination on Wafers
As the scale of integrated circuits (ICs) on semiconductors passes below 10 nm, efficient detection of organic contamination, like photoresist residue, and defects during wafer inspection is becoming…
![[Translate to German:] Evolved ARveo 8: Operating Room (OR) set-up.](/fileadmin/_processed_/6/3/csm_Evolved_ARveo_OR_MyVeo_Operating_Room_set-up_01_7f49e9f537.jpg "[Translate to German:] Evolved ARveo 8: Operating Room (OR) set-up.")
Augmented Reality: Transforming Neurosurgical Procedures
In this ebook, you will explore the exciting advances that Augmented Reality (AR) brings to the field of neurosurgery. This comprehensive guide, including explanatory videos, addresses key questions…
AI-Powered Multiplexed Image Analysis to Explore Colon Adenocarcinoma
In this application note, we demonstrate a spatial biology workflow via an AI-powered multiplexed image analysis-based exploration of the tumor immune microenvironment in colon adenocarcinoma.
Laser Microdissection Protocols for Tissue and Cell Isolation - Download free eBook
In this Bio-protocol Selections, we present a collection of open-access, detailed methods papers using LCM to purify and isolate tissues and cells from plants, mouse embryos, cancer cells, neurons,…
How do Cells Talk to Each Other During Neurodevelopment?
Professor Silvia Capello presents her group’s research on cellular crosstalk in neurodevelopmental disorders, using models such as cerebral organoids and assembloids.
Dual-View LightSheet Microscope for Large Multicellular Systems
Visualizing the dynamics of complex multicellular systems is a fundamental goal in biology. To address the challenges of live imaging over large spatiotemporal scales, Franziska Moos et. al. present…
A Meta-cancer Analysis of the Tumor Spatial Microenvironment
Learn how clustering analysis of Cell DIVE datasets in Aivia can be used to understand tissue-specific and pan-cancer mechanisms of cancer progression
Mapping the Landscape of Colorectal Adenocarcinoma with Imaging and AI
Discover deep insights in colon adenocarcinoma and other immuno-oncology realms through the potent combination of multiplexed imaging of Cell DIVE and Aivia AI-based image analysis
