Science Lab

Science Lab

Science Lab

Willkommen auf dem Wissensportal von Leica Microsystems. Hier finden Sie wissenschaftliches Forschungs- und Lehrmaterial rund um das Thema Mikroskopie. Das Portal unterstützt Anfänger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrer täglichen Arbeit und ihren Experimenten. Erkunden Sie interaktive Tutorials und Anwendungshinweise, entdecken Sie die Grundlagen der Mikroskopie ebenso wie High-End-Technologien. Werden Sie Teil der Science Lab Community und teilen Sie Ihr Fachwissen.
Image of magnetic steel taken with a 100x objective using Kerr microscopy. The magnetic domains in the grains appear in the image with lighter and darker patterns. A few domains are marked with red arrows. Courtesy of Florian Lang-Melzian, Robert Bosch GmbH, Germany.

Rapidly Visualizing Magnetic Domains in Steel with Kerr Microscopy

The rotation of polarized light after interaction with magnetic domains in a material, known as the Kerr effect, enables the investigation of magnetized samples with Kerr microscopy. It allows rapid…
Dr. Sheybani places the new subconjunctival stent in the anterior chamber. Images courtesy of Arsham Sheybani, MD.

Glaucoma Stent Revision Surgery Guided by Intraoperative OCT

Learn about a glaucoma subconjunctival stent revision guided by intraoperative OCT and the important role it plays to ensure the best outcome.
Automated wafer loader using carbon fiber end-effectors for safer handling.

Safe Wafer Loading for Microscope Inspection without Hand Contact

How automated silicon wafer loading for microscope inspection helps improve microelectronics process control and production efficiency is explained in this article. Manual handling of wafers has a…
Eine Batterieelektrode, deren Ränder Grate aufweisen (mit roten Pfeilen markiert). Das Bild wurde mit einem Digitalmikroskop DVM6 aufgenommen.

Graterkennung während der Batterieherstellung

Erfahren Sie, wie die optische Mikroskopie zur Graterkennung an Batterieelektroden und zur Bestimmung des Schadenspotenzials eingesetzt werden kann, um eine schnelle und zuverlässige…
Plastic reconstructive surgery with M530 OHX

Advances in Oncological Reconstructive Surgery

Decision making and patient care in oncological reconstructive surgery have considerably evolved in recent years. New surgical assistance technologies are helping surgeons push the boundaries of what…
Sectioning resin-embedded sambles

Ultramicrotomy eBook: Targeting, Trimming & Alignment

Ultramicrotomy is evolving rapidly, and today’s microscopes demand high‑quality sections, precise targeting, and reproducible workflows. This eBook brings together expert application notes, automated…
Surgical incision in minimally invasive spine surgery (MISS) case. Image courtesy of Dr. A. Alfieri, Chief Physician & Head of Clinic of Neurosurgery & Spinal Surgery, Cantonal Hospital Winterthur, Switzerland.

Flexibility and Efficiency in Minimally Invasive Spine Surgery

According to Prof. Alex Alfieri, Chief Physician and Head of clinic for Neurosurgery and Spinal surgery at the Cantonal Hospital Winterthur, Minimally invasive spine surgery (MISS) is transforming…
Foraminifera (Ammonia confertitesta) labeled with membrane-permeable calcein, high-pressure frozen in salt water using EM ICE. The sample was cryo-planed and targeted with the M205 on the Cryo-Fluo Enuity, then transferred under cryo conditions to the Cryo-Stellaris for widefield and confocal imaging, revealing details of the staining pattern. Image courtesy: David Evans, University of Southampton.

High-Pressure Freezing for Organoids: Cryo CLEM & FIB Lift Out

Master cryo EM workflow steps for challenging 3D samples: when to choose HPF vs. plunge freezing, reproducible blotting/ice control, contamination aware transfers, Cryo CLEM 3D targeting in organoids,…
Virally labeled neurons (red) and astrocytes (green) in a cortical spheroid derived from human induced pluripotent stem cells. THUNDER Model Organism Imager with a 2x, 0.15 NA objective at 3.4x zoom was used to produce this 425 µm Z-stack (26 positions) which is presented here as an Extended Depth of Field (EDoF) projection. Images courtesy of Dr. F. Birey, Dr. S. Pasca laboratory, Palo Alto, CA.

Guide to Live-Cell Imaging

For a wide range of applications in various research fields of life science, live-cell imaging is an indispensable tool for visualizing cells in a state as close to in vivo, i.e. living and active, as…
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