![Science Lab](/fileadmin/_processed_/6/0/csm_lms-sl-header_d2c38d8093.jpg)
Science Lab
Science Lab
Das Wissensportal von Leica Microsystems bietet Ihnen Wissens- und Lehrmaterial zu den Themen der Mikroskopie. Die Inhalte sind so konzipiert, dass sie Einsteiger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrem alltäglichen Vorgehen und Experimenten unterstützen. Entdecken Sie interaktive Tutorials und Anwendungsberichte, erfahren Sie mehr über die Grundlagen der Mikroskopie und High-End-Technologien - werden Sie Teil der Science Lab Community und teilen Sie Ihr Wissen!
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![Camera image during auto alignment. The feedback lines indicate if the correct edges in the image are detected. Green: Vertical center line Camera image during auto alignment. The feedback lines indicate if the correct edges in the image are detected. Green: Vertical center line; Magenta: Upper edge of the light gap; White: Lower edge of the light gap (not visible here, falling together with red line); Red: Knife edge; Blue: Left and right edge of the block face being automatically detected.](/fileadmin/_processed_/d/1/csm_Camera_image_during_auto_alignment_UC_Enuity_c148ecb865.jpg)
Automatic Alignment of Sample and Knife for High Sectioning Quality
Automatic alignment of sample and knife on the ultramicrotome UC Enuity, enabling even untrained users to create ultrathin sections with reduced risk of losing precious sections.
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![Section ribbons with increasing section thickness - silver to purple ending in blue sections. Section ribbons with increasing section thickness - silver to purple ending in blue sections.](/fileadmin/_processed_/7/2/csm_Section_ribbons_with_increasing_section_thickness_8b0ba46e79.jpg)
High Quality Sectioning in Ultramicrotomy
Discover the significance of achieving high-quality uniform sections with ultramicrotomy for precise imaging in electron microscopy.
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![Water Flea Daphnia imaged by Electron Microscopy. Courtesy of Mag. Dr. Gruber, University of Vienna, Austria. Water Flea Daphnia imaged by Electron Microscopy. Courtesy of Mag. Dr. Gruber, University of Vienna, Austria](/fileadmin/_processed_/e/d/csm_EM_Application_Water_Flea_Daphnia_7abc89f4fb.jpg)
Streamline your EM Sample Preparation Workflow for Biological Applications
Master EM sample preparation, including ultramicrotomy, for life sciences in this expert eBook!
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![Material sample with a large height, size, and weight being observed with an inverted microscope. Material sample with a large height, size, and weight being observed with an inverted microscope.](/fileadmin/_processed_/f/4/csm_Inverted_microscope_with_large_sample_crop_04c3257c81.jpg)
Five Inverted-Microscope Advantages for Industrial Applications
With inverted microscopes, you look at samples from below since their optics are placed under the sample, with upright microscopes you look at samples from above. Traditionally, inverted microscopes…
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![Image of an integrated-circuit (IC) chip cross section acquired at higher magnification showing a region of interest. Image of an integrated-circuit (IC) chip cross section acquired at higher magnification showing a region of interest.](/fileadmin/_processed_/a/c/csm_IC_chip_cross_section_20a5502a5d.jpg)
Structural and Chemical Analysis of IC-Chip Cross Sections
This article shows how electronic IC-chip cross sections can be efficiently and reliably prepared and then analyzed, both visually and chemically at the microscale, with the EM TXP and DM6 M LIBS…
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![EBSD grain size distribution of the cross section of a gold wire within a silicon matrix from inside a CPU (central processing unit of a computer). The grains are highlighted with arbitrary colors. EBSD grain size distribution of the cross section of a gold wire within a silicon matrix from inside a CPU (central processing unit of a computer). The grains are highlighted with arbitrary colors.](/fileadmin/_processed_/d/0/csm_EBSD_grain_size_distribution_of_the_cross_section_of_a_gold_wire_58f1fb038c.jpg)
High-Quality EBSD Sample Preparation
This article describes a method for EBSD sample preparation of challenging materials. The high-quality samples required for electron backscatter diffraction are prepared with broad ion-beam milling.
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![Mikroskopische Aufnahmen von Dinoflagellaten. Maßstabsbalken = 1 µm. Mikroskopische Aufnahmen von Dinoflagellaten. Maßstabsbalken = 1 µm.](/fileadmin/_processed_/2/1/csm_Small_planktonic_cell_c1c319f0b4.jpg)
Wie die Analyse von Meeresmikroorganismen durch Hochdruckgefrieren verbessert werden kann
Die ultrastrukturelle Analyse von Umweltproben, hier Dinoflagellaten, bleibt heutzutage eine Herausforderung. Hier zeigen wir, dass die Durchführung von Hochdruckgefrieren (HPF) vor Ort die…
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![Projection of a confocal z-stack. Sum159 cells, human breast cancer cells Projection of a confocal z-stack. Sum159 cells, human breast cancer cells kindly provided by Ievgeniia Zagoriy, Mahamid Group, EMBL Heidelberg, Germany. Blue–Hoechst - indicates nuclei, Green–MitoTracker mitochondria, and red–Bodipy - lipid droplets](/fileadmin/_processed_/6/6/csm_Keyvisual-Cancer-cell-under-Cryo_Coral-Cryo_TechNote_99f1c3cd0c.jpg)
New Imaging Tools for Cryo-Light Microscopy
New cryo-light microscopy techniques like LIGHTNING and TauSense fluorescence lifetime-based tools reveal structures for cryo-electron microscopy.
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![Correlation of markers in the LM and the FIB image. Correlation of markers in the LM and the FIB image.](/fileadmin/_processed_/7/f/csm_Correlation_of_markers_in_the_LM_and_the_FIB_image_teaser_33ce8a2e69.jpg)
How to Target Fluorescent Structures in 3D for Cryo-FIB Milling
This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in…