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Science Lab
Science Lab
Das Wissensportal von Leica Microsystems bietet Ihnen Wissens- und Lehrmaterial zu den Themen der Mikroskopie. Die Inhalte sind so konzipiert, dass sie Einsteiger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrem alltäglichen Vorgehen und Experimenten unterstützen. Entdecken Sie interaktive Tutorials und Anwendungsberichte, erfahren Sie mehr über die Grundlagen der Mikroskopie und High-End-Technologien - werden Sie Teil der Science Lab Community und teilen Sie Ihr Wissen!
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![Image of murine dopaminergic neurons which have been marked for laser microdissection (LMD). Image of murine dopaminergic neurons which have been marked for laser microdissection (LMD).](/fileadmin/_processed_/b/f/csm_Murine_dopaminergic_neurons_marked_for_LMD_cdc0cd9eda.jpg)
Neuron Isolation in Spatial Context with Laser Microdissection (LMD)
After Alzheimer’s disease, Parkinson’s is the second most common progressive neurodegenerative disease. Before the first symptoms manifest, up to 70% of dopamine-releasing neurons in the mid-brain…
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How did Laser Microdissection enable Pioneering Neuroscience Research?
Dr. Marta Paterlini, a Senior Scientist at the Karolinska Institute, shares her experience of using laser microdissection (LMD) in groundbreaking research into adult human neurogenesis and offers…
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Laser Microdissection Protocols for Tissue and Cell Isolation - Download free eBook
In this Bio-protocol Selections, we present a collection of open-access, detailed methods papers using LCM to purify and isolate tissues and cells from plants, mouse embryos, cancer cells, neurons,…
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![Single cell datasets Single cell datasets](/fileadmin/_processed_/8/8/csm_Single_cell_datasets_SPARCS_441a58445d.jpg)
Exploring Subcellular Spatial Phenotypes with SPARCS
Discover spatially resolved CRISPR screening (SPARCS), a platform for microscopy-based genetic screening for spatial subcellular phenotypes at the human genome scale.
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![How is microscopy used in spatial biology? A microscopy guide. How is microscopy used in spatial biology - Teaserimage](/fileadmin/_processed_/0/f/csm_spatial-biology-ebook-tease_5ac6218fa3.jpg)
How is Microscopy Used in Spatial Biology? A Microscopy Guide
Different spatial biology methods in microscopy, such as multiplex imaging, are helping to better understand tissue landscapes. Learn more in this microscopy guide.
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![Automated Laser Microdissection for Proteome Analysis Automated Laser Microdissection for Proteome Analysis](/fileadmin/_processed_/9/6/csm_lmd-article-precise_0a4ed2da36.jpg)
Precise Spatial Proteomic Information in Tissues
Despite the availability of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance…
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![Image of murine-brain tissue showing a region removed with UV laser microdissection. Image of murine-brain tissue showing a region removed with UV laser microdissection.](/fileadmin/_processed_/a/4/csm_Murine-brain_tissue_showing_a_region_removed_with_UV_LMD_e02d1597b3.jpg)
RNA Quality after Different Tissue Sample Preparation
The influence of sample preparation and ultraviolet (UV) laser microdissection (UV LMD) on the quality of RNA from murine-brain tissue cryo-sections is described in this article. To obtain good…
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Dissecting Proteomic Heterogeneity of the Tumor Microenvironment
This lecture will highlight cutting edge applications in applying laser microdissection and microscaled quantitative proteomics and phosphoproteomics to uncover exquisite intra- and inter-tumor…
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20 Years of Leica Laser Microdissection
Phenotype-genotype correlations are key for insight. From Eye to Insight is therefore fitting perfectly to Leica Microsystems and in particular to laser microdissection. Laser Microdissection, also…