![Science Lab](/fileadmin/_processed_/6/0/csm_lms-sl-header_d2c38d8093.jpg)
Science Lab
Science Lab
Das Wissensportal von Leica Microsystems bietet Ihnen Wissens- und Lehrmaterial zu den Themen der Mikroskopie. Die Inhalte sind so konzipiert, dass sie Einsteiger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrem alltäglichen Vorgehen und Experimenten unterstützen. Entdecken Sie interaktive Tutorials und Anwendungsberichte, erfahren Sie mehr über die Grundlagen der Mikroskopie und High-End-Technologien - werden Sie Teil der Science Lab Community und teilen Sie Ihr Wissen!
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![THY1-EGFP labeled neurons in mouse brain processed using the PEGASOS 2 tissue clearing method. Neurons were traced using Aivia’s 3D Neuron Analysis – FL recipe. Image credit: Hu Zhao, Chinese Institute for Brain Research. THY1-EGFP labeled neurons in mouse brain processed using the PEGASOS 2 tissue clearing method, imaged on a Leica confocal microscope. Neurons were traced using Aivia’s 3D Neuron Analysis – FL recipe. Image credit: Hu Zhao, Chinese Institute for Brain Research.](/fileadmin/_processed_/f/1/csm_Neurons_in_mouse_brain_with_Aivia_3D_Neuron_Analysis_9aa755e1c5.jpg)
Unlocking Insights in Complex and Dense Neuron Images Guided by AI
The latest advancement in Aivia AI image analysis software provides improved soma detection, additional flexibility in neuron tracing, 3D relational measurement including Sholl analysis and more.
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![Microscopy for neuroscience research Microscopy for neuroscience research](/fileadmin/_processed_/9/5/csm_Microscopy_for_neuroscience_research_cc303ca353.jpg)
What are the Challenges in Neuroscience Microscopy?
eBook outlining the visualization of the nervous system using different types of microscopy techniques and methods to address questions in neuroscience.
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![AI-based workflow for fast rare event detection in living biological samples using Autonomous Microscopy powered by Aivia AI-based workflow for fast rare event detection in living biological samples using Autonomous Microscopy powered by Aivia](/fileadmin/_processed_/c/5/csm_AI-Workfow_rare-event-detection_bcd9e88450.jpg)
AI Microscopy Enables the Efficient Detection of Rare Events
Localization and selective imaging of rare events is key for the investigation of many processes in biological samples. Yet, due to time constraints and complexity, some experiments are not feasible…
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![Krebszellen Krebszellen](/fileadmin/_processed_/6/b/csm_Cancer_cells_0188d06359.jpg)
Die Rolle des Eisenstoffwechsels bei der Krebsentwicklung
Der Eisenstoffwechsel spielt eine Rolle bei der Entstehung und dem Fortschreiten von Krebs und beeinflusst die Immunreaktion. Zu verstehen, wie Eisen Krebs und das Immunsystem beeinflusst, kann die…
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![Raw widefield and THUNDER image of calcium transients in Drosophila embryos. Courtesy A. Carreira-Rosario, Clandinin laboratory, California, USA. Raw widefield and THUNDER image of calcium transients in Drosophila embryos. Courtesy A. Carreira-Rosario, Clandinin laboratory, California, USA.](/fileadmin/_processed_/7/6/csm_Calcium_transients_in_Drosophila_embryos_teaser_fcd31bd78f.jpg)
Central Nervous System (CNS) Development and Activity in Organisms
This article shows how studying central nervous system (CNS) development in Drosophila-melanogaster embryos expressing a GCaMP calcium indicator in the neurons can be improved with a THUNDER Imager.
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![How is microscopy used in spatial biology? A microscopy guide. How is microscopy used in spatial biology - Teaserimage](/fileadmin/_processed_/0/f/csm_spatial-biology-ebook-tease_5ac6218fa3.jpg)
How is Microscopy Used in Spatial Biology? A Microscopy Guide
Different spatial biology methods in microscopy, such as multiplex imaging, are helping to better understand tissue landscapes. Learn more in this microscopy guide.
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![Raw widefield and THUNDER image of transversal mouse adult fiber lens section. Courtesy N. Houssin, Plagemen lab, Ohio State University, Columbus, USA. Raw widefield and THUNDER image of transversal mouse adult fiber lens section. Courtesy N. Houssin, Plagemen lab, Ohio State University, Columbus, USA.](/fileadmin/_processed_/3/0/csm_Transversal_mouse_adult_fiber_lens_section_Widefield_THUNDER_teaser_6f95700ba0.jpg)
Studying Ocular Birth Defects
This article discusses how lens formation and ocular birth defects can be studied with sharp widefield microscopy images which are acquired rapidly. The mouse ocular lens is used as a model to study…
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![Automated Laser Microdissection for Proteome Analysis Automated Laser Microdissection for Proteome Analysis](/fileadmin/_processed_/9/6/csm_lmd-article-precise_0a4ed2da36.jpg)
Precise Spatial Proteomic Information in Tissues
Despite the availability of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance…
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![Image of murine-brain tissue showing a region removed with UV laser microdissection. Image of murine-brain tissue showing a region removed with UV laser microdissection.](/fileadmin/_processed_/a/4/csm_Murine-brain_tissue_showing_a_region_removed_with_UV_LMD_e02d1597b3.jpg)
RNA Quality after Different Tissue Sample Preparation
The influence of sample preparation and ultraviolet (UV) laser microdissection (UV LMD) on the quality of RNA from murine-brain tissue cryo-sections is described in this article. To obtain good…