Science Lab

Science Lab

Science Lab

Das Wissensportal von Leica Microsystems bietet Ihnen Wissens- und Lehrmaterial zu den Themen der Mikroskopie. Die Inhalte sind so konzipiert, dass sie Einsteiger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrem alltäglichen Vorgehen und Experimenten unterstützen. Entdecken Sie interaktive Tutorials und Anwendungsberichte, erfahren Sie mehr über die Grundlagen der Mikroskopie und High-End-Technologien - werden Sie Teil der Science Lab Community und teilen Sie Ihr Wissen!

Krebsforschung

Krebs ist eine komplexe und heterogene Krankheit, die durch Zellen verursacht wird, denen die Wachstumsregulation fehlt. Genetische und epigenetische Veränderungen in einer Zelle oder einer Gruppe von…
Pancreatic Ductal Adenocarcinoma with 11 Aerobic Glycolysis/Warburg Effect biomarkers shown – BCAT, Glut1, HK2, HTR2B, LDHA, NaKATPase, PCAD, PCK26, PKM2, SMA1, and Vimentin.

Dive into Pancreatic Cancer Research with Big Data

Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC),…
Colon adenocarcinoma and normal colon at the tumor margin. 13 biomarkers shown including Cadherin, CD3, CD4, CD8, CD20, CD31, CD45, Collagen, Caspase 9, BCL2, Beta-Catenin, Vimentin, and Smooth Muscle Actin.

Uncover the Hidden Complexity of Colon Cancer with Big Data

Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like…

Neurowissenschaften

Arbeiten Sie an einem besseren Verständnis neurodegenerativer Erkrankungen oder an einer Untersuchung der Funktionen des Nervensystems? Erfahren Sie, wie Sie mit Bildgebungslösungen von Leica…
Cell DIVE multiplexed image of FFPE tissue section from syngeneic murine cancer model, 4T1.

Mapping Tumor Immune Landscape with AI-Powered Spatial Proteomics

Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying…
Automated Laser Microdissection for Proteome Analysis

Deep Visual Proteomics Provides Precise Spatial Proteomic Information

Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance…
Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s brain tissue section demonstrating expression of markers specific to astrocytes (GFAP, S100B), microglia (TMEM119, IBA1), AD-associated markers (p-Tau217, β-amyloid) and immune cells such as CD11b+, CD163+, CD4+, and HLA-DRA+, clustered around the β-amyloid plaques.

Spatial Analysis of Neuroimmune Interactions in Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by neurofibrillary tangles, β-amyloid plaques, and neuroinflammation. These dysfunctions trigger or are exacerbated by…
Pancreatic Ductal Adenocarcinoma imaged with Cell DIVE. Analysis done by Aivia.

A Guide to Spatial Biology

What is spatial biology, and how can researchers leverage its tools to meet the growing demands of biological questions in the post-omics era? This article provides a brief overview of spatial biology…
Multiplexed Cell DIVE imaging to characterize the spatial landscape in Human Alzheimer’s Cortical Tissue

Probing Human Alzheimer's Cortical Section using Spatial Multiplexing

Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by the progressive decline of cognitive function. Spatial profiling of AD brain may reveal cellular…
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