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Science Lab
Science Lab
Das Wissensportal von Leica Microsystems bietet Ihnen Wissens- und Lehrmaterial zu den Themen der Mikroskopie. Die Inhalte sind so konzipiert, dass sie Einsteiger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrem alltäglichen Vorgehen und Experimenten unterstützen. Entdecken Sie interaktive Tutorials und Anwendungsberichte, erfahren Sie mehr über die Grundlagen der Mikroskopie und High-End-Technologien - werden Sie Teil der Science Lab Community und teilen Sie Ihr Wissen!
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![Multiplexed Cell DIVE imaging to characterize the tumor immune microenvironment in human colon adenocarcinoma (CAC) tissue.](/fileadmin/_processed_/4/a/csm_Human_colon_adenocarcinoma_CAC_tissue_b6afb685f3.jpg)
AI-Powered Multiplexed Image Analysis to Explore Colon Adenocarcinoma
In this application note, we demonstrate a spatial biology workflow via an AI-powered multiplexed image analysis-based exploration of the tumor immune microenvironment in colon adenocarcinoma.
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![According to Dr. Flanagan, the PROvido IVA surgical microscope provides optimal visualization, supporting the needs of tympanoplasty surgery. Image courtesy of Dr. Sean Flanagan. According to Dr. Flanagan, the PROvido IVA surgical microscope provides optimal visualization, supporting the needs of tympanoplasty surgery. Image courtesy of Dr. Sean Flanagan.](/fileadmin/_processed_/e/e/csm_Tympanoplasty_surgery_with_PROvido_IVA_by_Dr._Flanagan_041d639b09.jpg)
Tympanoplasty Surgery: Optimal Approaches and Tools
Discover tympanoplasty surgery case studies illustrating the standard approaches: post-auricular, endaural and transcanal. Gain insights from Dr. Flanagan on selecting the adequate surgical approach…
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![Intestinal organoids label with FUCCI reporter to follow cell cycle dynamics. Courtesy of Franziska Moos. Liberali lab. FMI Basel (Switzerland). Intestinal organoids label with FUCCI reporter to follow cell cycle dynamics. Courtesy of Franziska Moos. Liberali lab. FMI Basel (Switzerland).](/fileadmin/_processed_/3/0/csm_Explore-life-events-with-long-term-imaging_e9ce5f5ea8.jpg)
Dual-View LightSheet Microscope for Large Multicellular Systems
Visualizing the dynamics of complex multicellular systems is a fundamental goal in biology. To address the challenges of live imaging over large spatiotemporal scales, Franziska Moos et. al. present…
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![Multiplexed Cell DIVE imaging of selected clusters and unique cell populations identified in mucinous cystadenocarcinoma of the ovary.](/fileadmin/_processed_/8/6/csm_Cell_populations_identified_in_mucinous_cystadenocarcinoma_of_ovary_d43ca4a170.jpg)
A Meta-cancer Analysis of the Tumor Spatial Microenvironment
Learn how clustering analysis of Cell DIVE datasets in Aivia can be used to understand tissue-specific and pan-cancer mechanisms of cancer progression
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![Multiplexed Cell DIVE imaging of Colon Adenocarcinoma (CAC) tissue. Multiplexed Cell DIVE imaging of Colon Adenocarcinoma (CAC) tissue. A panel of approximately 30 biomarkers targeted towards various leukocyte lineages, epithelial, stromal, and endothelial cell types was utilized to characterize the tumor immune microenvironment in human colon adenocarcinoma (CAC) tissue.](/fileadmin/_processed_/c/7/csm_Colon_Adenocarcinoma_CAC_tissue_multiplexed_Cell_DIVE_image_427e3f34d4.jpg)
Mapping the Landscape of Colorectal Adenocarcinoma with Imaging and AI
Discover deep insights in colon adenocarcinoma and other immuno-oncology realms through the potent combination of multiplexed imaging of Cell DIVE and Aivia AI-based image analysis
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![Clustering based analysis reveals various immune cell populations enriched in tumor cells within CT26.WT syngeneic mouse tumor models. Clustering based analysis reveals various immune cell populations enriched in tumor cells within CT26.WT syngeneic mouse tumor models.](/fileadmin/_processed_/f/e/csm_Immune_cells_in_tumor_cells_within_CT26WT_syngeneic_mouse_tumor_models_7de627c156.jpg)
Spatial Architecture of Tumor and Immune Cells in Tumor Tissues
Dig deep into the spatial biology of cancer progression and mouse immune-oncology in this poster, and learn how tumor metabolism can effect immune cell function.
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![Pancreatic Ductal Adenocarcinoma with 11 Aerobic Glycolysis/Warburg Effect biomarkers shown – BCAT, Glut1, HK2, HTR2B, LDHA, NaKATPase, PCAD, PCK26, PKM2, SMA1, and Vimentin. Pancreatic Ductal Adenocarcinoma with 11 Aerobic Glycolysis/Warburg Effect biomarkers shown – BCAT, Glut1, HK2, HTR2B, LDHA, NaKATPase, PCAD, PCK26, PKM2, SMA1, and Vimentin.](/fileadmin/_processed_/d/d/csm_Pancreatic_Ductal_Adenocarcinoma_11_Aerobic_Glycolysis_Markers_ROI3_0845a47193.jpg)
IBEX, Cell DIVE, and RNA-Seq: A Multi-omics Approach to Follicular Lymphoma
In a recent study by Radtke et al., a multi-omics spatial biology approach helps shed light on early relapsing lymphoma patients
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![](/fileadmin/_processed_/8/e/csm_Subretinal_gene_therapy_injection_Dr_Nerinckx_OCT_cf81de4f46.jpg)
RPE65 Gene Therapy Subretinal Injection: Benefits of Intraoperative OCT
Discover how RPE65 gene therapy subretinal injection procedures in patients with Leber congenital amaurosis is supported by intraoperative Optical Coherence Tomography.
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![Applying dispersive viscoelastic to coat the anterior chamber. Image courtesy of Arsham Sheybani, MD, Washington University School of Medicine. Applying dispersive viscoelastic to coat the anterior chamber. Image courtesy of Arsham Sheybani, MD, Washington University School of Medicine.](/fileadmin/_processed_/6/3/csm_Applying_dispersive_viscoelastic_to_coat_the_anterior_chamber_d1c42722e0.jpg)
Dislocated Cataract Angle Closure Aided by Intraoperative OCT
Learn how a dislocated cataract was treated with angle closure assisted by intraoperative OCT to achieve long-term good results without future lens dislocation.