Science Lab

Science Lab

Science Lab

Willkommen auf dem Wissensportal von Leica Microsystems. Hier finden Sie wissenschaftliches Forschungs- und Lehrmaterial rund um das Thema Mikroskopie. Das Portal unterstützt Anfänger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrer täglichen Arbeit und ihren Experimenten. Erkunden Sie interaktive Tutorials und Anwendungshinweise, entdecken Sie die Grundlagen der Mikroskopie ebenso wie High-End-Technologien. Werden Sie Teil der Science Lab Community und teilen Sie Ihr Fachwissen.
Area of a printed circuit board (PCB) which was imaged with extended depth of field (EDOF) using digital microscopy.

Depth of Field in Microscope Images

For microscopy imaging, depth of field is an important parameter when needing sharp images of sample areas with structures having significant changes in depth. In practice, depth of field is…

DIC

Ein DIC-Mikroskop ist ein Weitfeldmikroskop, bei dem sich zwischen Lichtquelle und Kondensorlinse sowie zwischen Objektiv und Kamerasensor oder Okularen ein Polarisationsfilter und ein…
Automated Laser Microdissection for Proteome Analysis

Deep Visual Proteomics Provides Precise Spatial Proteomic Information

Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance…
These images show the microstructure of a hard metal with 10% cobalt which is used for heavy-duty tools. The large increase in magnification of the right image (compared to the left) has a risk of being outside the useful range or, in other words, empty magnification.

What is Empty Magnification and How can Users Avoid it

The phenomenon of “empty magnification”, which can occur while using an optical, light, or digital microscope, and how it can be avoided is explained in this article. The performance of an optical…
Leitz Laborlux: Tartaric acids, polarization contrast

Das Prinzip der Polarisationsmikroskopie

Die Polarisationsmikroskopie wird in den Material- und Geowissenschaften routinemäßig eingesetzt, um Materialien und Mineralien anhand ihrer charakteristischen Brechungseigenschaften und Farben zu…
Stripe assay performed on a THUNDER Imager Cell. Courtesy of Maria Carrasquero Ordaz, University of Oxford.

Revealing Neuronal Migration’s Molecular Secrets

Different approaches can be used to investigate neuronal migration to their niche in the developing brain. In this webinar, experts from The University of Oxford present the microscopy tools and…
Cell DIVE image of stromal remodeling around B cell follicles of follicular lymphoma patients. Stromal cells labeled with antibodies against desmin (red), SPARC (orange), vimentin (blue), and a-sma (yellow). Extracellular matrix labeled with antibody against lumican (cyan). B cells labeled with antibody against CD20 (green). Image credit: Dr. Andrea Radtke, Center for Advanced Tissue Imaging, NIAID, NIH

Empowering Spatial Biology with Open Multiplexing and Cell DIVE

Spatial biology and multiplexed imaging workflows have become important in immuno-oncology research. Many researchers struggle with study efficiency, even with effective tools and protocols. Here, we…

How did Laser Microdissection enable Pioneering Neuroscience Research?

Dr. Marta Paterlini, a Senior Scientist at the Karolinska Institute, shares her experience of using laser microdissection (LMD) in groundbreaking research into adult human neurogenesis and offers…
The role of extracellular signalling mechanisms in the correct development of the human brain

How do Cells Talk to Each Other During Neurodevelopment?

Professor Silvia Capello presents her group’s research on cellular crosstalk in neurodevelopmental disorders, using models such as cerebral organoids and assembloids.
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