Science Lab

Science Lab

Science Lab

Bienvenido al portal de conocimiento de Leica Microsystems. Aquí encontrará investigación científica y material didáctico sobre el tema de la microscopía. El portal ayuda a principiantes, profesionales experimentados y científicos por igual en su trabajo diario y en sus experimentos. Explore tutoriales interactivos y notas de aplicación, descubra los fundamentos de la microscopía, así como las tecnologías de gama alta. Forme parte de la comunidad Science Lab y comparta sus conocimientos.
These images illustrate the need for multiple z-slices to capture all gH2Ax foci in a given cell and get an accurate count.

Development and Derisking of CRISPR Therapies for Rare Diseases

This on-demand presentation by Dr. Fyodor Urnov and Dr. Sadik Kassim, originally delivered at ASGCT 2025, focused on a critical challenge in genetic medicine: how to scale CRISPR therapies from…
Example of calibrating a microscope at a higher magnification value using a stage micrometer.

Microscope Calibration for Measurements: Why and How You Should Do It

Microscope calibration ensures accurate and consistent measurements for inspection, quality control (QC), failure analysis, and research and development (R&D). Calibration steps are described in this…

Integrated Serial Sectioning and Cryo-EM Workflows for 3D Biological Imaging

This on-demand webinar explores how integrated tools can support electron microscopy workflows from sample preparation to image analysis. Experts Andreia Pinto, Adrian Boey, and Hoyin Lai present the…
SEM image of the full Li-NMC electrode sample, showing the two porous layers and the metal film at the center of the structure.

Revealing Sodium Battery Degradation via Cryo-EM and CryoFIB

Explore how cryogenic electron microscopy and focused ion beam techniques uncover the intrinsic structure of sodium battery interfaces. This webinar presents a new degradation model based on separator…
Cell DIVE multiplexed image of FFPE tissue section from human colon adenocarcinoma tissue.

Multiplexed Imaging Reveals Tumor Immune Landscape in Colon Cancer

Cancer immunotherapy benefits few due to resistance and relapse, and combinatorial therapeutic strategies that target multiple steps of the cancer-immunity cycle may improve outcomes. This study shows…
Cell DIVE multiplexed image of FFPE tissue section from human invasive ductal carcinoma (IDC)

AI-Powered Hi-Plex Spatial Analysis Tools for Breast Cancer Research

Breast cancer (BC) is the leading cause of cancer-related deaths in women. Investigating the tumor microenvironment (TME) is crucial to elucidate the mechanisms of tumor progression. Systematic…
Mouse brain slice which was immunostained with GFAP-A647 and imaged using a THUNDER Imager Tissue. Courtesy of H. Xu, University of Pennsylvania, Philadelphia, USA.

Neurociencia

¿Trabaja para comprender mejor las enfermedades neurodegenerativas o la función del sistema nervioso? Vea cómo puede conseguir descubrimientos con las soluciones de imágenes de Leica Microsystems.
Mouse hippocampus brain slice on a grid after HPF using the “Waffle Method”.

The “Waffle Method”: High-Pressure Freeze Complex Samples

This article describes the advantages of a special high pressure freezing method, the so-called “Waffle Method”. Learn how the “Waffle Method” uses EM grids as spacers for high-pressure freezing,…
UC Enuity with Diatome diamond knife.

Mastering Polymer Sectioning with Helmut Gnaegi

When it comes to ultramicrotomy, few names carry the weight of Helmut Gnaegi. As co-founder of Diatome, a global leader in diamond knife technology, Helmut has spent decades refining the art and…
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