STELLARIS FALCON FLIM Microscope

LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) in immune cells
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH.
Autophagy, 2022
10.1080/15548627.2021.1954779

Phosphatidic acid suppresses autophagy through competitive inhibition by binding GAPC (glyceraldehyde-3-phosphate dehydrogenase) and PGK (phosphoglycerate kinase) proteins
Guan B, Jiang YT, Lin DL, Lin WH, Xue HW.
Autophagy, 2022
10.1080/15548627.2022.2046449

Molecular sensors reveal the mechano-chemical response of Phytophthora infestans walls and membranes to mechanical and chemical stress
Michels L, Bronkhorst J, Kasteel M, de Jong D, Albada B, Ketelaar T, Govers F, Sprakel J.
Cell Surf, 2022
10.1016/j.tcsw.2021.100071

In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope
Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Głuszek A, Łaszczych Z, Karnowski K, Soboń G, Palczewski K, Wojtkowski M.
J Clin Invest, 2022
10.1172/JCI154218

Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis
Vu T, Vallmitjana A, Gu J, La K, Xu Q, Flores J, Zimak J, Shiu J, Hosohama L, Wu J, Douglas C, Waterman ML, Ganesan A, Hedde PN, Gratton E, Zhao W.
Nat Commun, 2022
10.1038/s41467-021-27798-0

A pair of transporters controls mitochondrial Zn(2+) levels to maintain mitochondrial homeostasis
Ma T, Zhao L, Zhang J, Tang R, Wang X, Liu N, Zhang Q, Wang F, Li M, Shan Q, Yang Y, Yin Q, Yang L, Gan Q, Yang C.
Protein Cell, 2022
10.1007/s13238-021-00881-4

Hybrid 0D Antimony Halides as Air-Stable Luminophores for High-Spatial-Resolution Remote Thermography
Morad V, Yakunin S, Benin BM, Shynkarenko Y, Grotevent MJ, Shorubalko I, Boehme SC, Kovalenko MV.
Adv Mater, 2021
10.1002/adma.202007355

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress
Shytaj IL, Procopio FA, Tarek M, Carlon-Andres I, Tang HY, Goldman AR, Munshi M, Kumar Pal V, Forcato M, Sreeram S, Leskov K, Ye F, Lucic B, Cruz N, Ndhlovu LC, Bicciato S, Padilla-Parra S, Diaz RS, Singh A, Lusic M, Karn J, Alvarez-Carbonell D, Savarino A.
EMBO Mol Med, 2021
10.15252/emmm.202013901

A self-organized synthetic morphogenic liposome responds with shape changes to local light cues
Gavriljuk K, Scocozza B, Ghasemalizadeh F, Seidel H, Nandan AP, Campos-Medina M, Schmick M, Koseska A, Bastiaens PIH.
Nat Commun, 2021
10.1038/s41467-021-21679-2

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE.
Nat Commun, 2021
10.1038/s41467-021-26983-5

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action
Kast F, Schwill M, Stüber JC, Pfundstein S, Nagy-Davidescu G, Rodríguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Plückthun A.
Nat Commun, 2021
10.1038/s41467-021-23948-6

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
Cuevas-Velazquez CL, Vellosillo T, Guadalupe K, Schmidt HB, Yu F, Moses D, Brophy JAN, Cosio-Acosta D, Das A, Wang L, Jones AM, Covarrubias AA, Sukenik S, Dinneny JR.
Nat Commun, 2021
10.1038/s41467-021-25736-8

Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
Ojima K, Shiraiwa K, Soga K, Doura T, Takato M, Komatsu K, Yuzaki M, Hamachi I, Kiyonaka S.
Nat Commun, 2021
10.1038/s41467-021-21082-x

N-aryl pyrido cyanine derivatives are nuclear and organelle DNA markers for two-photon and super-resolution imaging
Uno K, Sugimoto N, Sato Y.
Nat Commun, 2021
10.1038/s41467-021-23019-w

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses
Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V.
Nat Immunol, 2021
10.1038/s41590-021-01064-3

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR.
Nature, 2021
10.1038/s41586-021-03341-5

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla A, Sengupta S, Ye Z, Yang C, Mitra J, De-Paula RB, Hegde ML, Ahmed Z, Mort M, Cooper DN, Mitra S, Tainer JA.
Nucleic Acids Res, 2021
10.1093/nar/gkaa1120

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA.
Sci Adv, 2021
10.1126/sciadv.abf3873

Calcium-dependent protein kinase 29 modulates PIN-FORMED polarity and Arabidopsis development via its own phosphorylation code
Lee H, Ganguly A, Baik S, Cho HT.
Plant Cell, 2021
10.1093/plcell/koab207

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, D'Sa K, Reynolds RH, Botía JA, Losa M, Lysenko V, Carta M, Heinzer D, Avar M, Chincisan A, Blauwendraat C, García-Ruiz S, Pease D, Mottier L, Carrella A, Beck-Schneider D, Magalhães AD, Aemisegger C, Theocharides APA, Fan Z, Marks JD, Hopp SC, Abramov AY, Lewis PA, Ryten M, Hardy J, Hyman BT, Aguzzi A.
Cell Rep, 2021
10.1016/j.celrep.2021.109189

Label-free identification and differentiation of different microplastics using phasor analysis of fluorescence lifetime imaging microscopy (FLIM)-generated data
Monteleone A, Schary W, Wenzel F, Langhals H, Dietrich DR.
Chem Biol Interact, 2021
10.1016/j.cbi.2021.109466

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes
Wang Z, Gurlo T, Matveyenko AV, Elashoff D, Wang P, Rosenberger M, Junge JA, Stevens RC, White KL, Fraser SE, Butler PC.
Commun Biol, 2021
10.1038/s42003-021-02113-1

Complex wavelet filter improves FLIM phasors for photon starved imaging experiments
Wang P, Hecht F, Ossato G, Tille S, Fraser SE, Junge JA.
Biomed Opt Express, 2021
10.1364/BOE.420953

New application for the identification and differentiation of microplastics based on fluorescence lifetime imaging microscopy (FLIM)
Monteleone A, Wenzel F, Langhals H, Dietrich D.
J Environmental Chemical Engineering,, 2021
10.1016/j.jece.2020.104769

Estimation of the Mitochondrial Membrane Potential Using Fluorescence Lifetime Imaging Microscopy
Okkelman IA, Papkovsky DB, Dmitriev RI.
Cytometry A, 2020
10.1002/cyto.a.23886

Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages
Peng H, Borg RE, Dow LP, Pruitt BL, Chen IA.
Proc Natl Acad Sci U S A, 2020
10.1073/pnas.1913234117

Quantitative FRET-FLIM-BlaM to Assess the Extent of HIV-1 Fusion in Live Cells
Carlon-Andres I, Padilla-Parra S.
Viruses, 2020
10.3390/v12020206

Single-cell glycolytic activity regulates membrane tension and HIV-1 fusion
Coomer CA, Carlon-Andres I, Iliopoulou M, Dustin ML, Compeer EB, Compton AA, Padilla-Parra S.
PLoS Pathog, 2020
10.1371/journal.ppat.1008359

Noninvasive two-photon optical biopsy of retinal fluorophores
Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K.
Proc Natl Acad Sci U S A, 2020
10.1073/pnas.2007527117

High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy
Schneider F, Hernandez-Varas P, Christoffer Lagerholm B, Shrestha D, Sezgin E, Julia Roberti M, Ossato G, Hecht F, Eggeling C, Urbančič I.
J Phys D Appl Phys, 2020
10.1088/1361-6463/ab6cca

TRPM7 residue S1269 mediates cAMP dependence of Ca2+ influx
Broertjes J, Klarenbeek J, Habani Y, Langeslag M, Jalink K.
PLoS One, 2019
10.1371/journal.pone.0209563

An essential role for the Zn(2+) transporter ZIP7 in B cell development
Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S.
Nat Immunol, 2019
10.1038/s41590-018-0295-8

SP8 FALCON: a novel concept in fluorescence lifetime imaging enabling video-rate confocal FLIM
Alvarez L, Widzgowski B, Ossato G, van den Broek B, Jalink K, Kuschel L, Roberti J, Hecht F.
Nat Methods, 2019
https://www.nature.com/articles/d42473-019-00261-x