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Do you need to produce thin or ultra-thin sections for EM sample preparation?
Introducing UC Enuity, the next generation ultramicrotome that saves you valuable time and resources through its automated setup functions, providing state-of-the-art sectioning quality.
The UC Enuity Cryo is a fully outfitted ultramicrotome for basic room temperature ultramicrotomy applications as well as advanced cryoultramicrotomy applications. It includes an antistatic device as well as a dual micromanipulator system to facilitate Tokuyasu and CEMOVIS applications. The system can also be upgraded for more advanced room temperature applications such as automated trimming and alignment, automated serial sectioning for VolumeEM or automated trimming guided by microCT data.
The UC Enuity Advanced is a fully outfitted ultramicrotome for advanced room temperature ultramicrotomy applications. It features an integrated camera and motorized segment arc and knife block to enable fully automated trimming of samples and automatic alignment of the knife to the sample. The UC Enuity Advanced can be upgraded for further room temperature applications such as automated serial sectioning for VolumeEM or automated trimming guided by microCT data, or for cryosectioning applications with the addition of the cryo chamber.
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I had the opportunity to use the new UC Enuity, and I was particularly impressed by the motorized knife block and segment arc. These features enable precise adjustment of small angles and allow for accurate rotation of the sample by setting a defined degree. Another notable feature is the Auto-Trim function, which is especially helpful for beginners who may struggle with aligning the sample to the knife. While experienced users might align the sample faster manually, the Auto-Trim function can still save time, allowing them to focus on other tasks. The new UC Enuity will simplify the cutting process.
UC Enuity allows you to monitor the fluorescence signal during sectioning at both room temperature and in cryo conditions.
Quickly identify your region of interest in the resin block.
Trim your target with the help of fluorescence.
Make every section count for volume EM experiments
Speed up your volume EM research with UC Enuity. Prepare uniform, ultra-thin and thin ribbons for your array tomography experiments, at reduced risk of losing precious sections.
You can collect uniformly aligned ultra-thin sections straight on the wafer, for fast and reliable transfer into the electron microscope.
Three consecutive ribbons for Array Tomography, 30 sections each, 70 nm feed. The ribbons were prepared with UC Enuity Volume EM module. After automatically cutting the ribbons, UC Enuity added two release cuts of 100 nm thickness at the end of each ribbon.
Unlock the full potential of ultramicrotomy
Elevate your research journey with an easily upgradable ultramicrotome, empowering you to expand capabilities and maximize the scientific potential of your experiments.
Upgrade your ultramicrotome with additional modules
Start with the basic UC Enuity instrument and seamlessly upgrade with add-on modules to a fully featured system equipped for your specific needs.
Easily upgradable ultramicrotome, empowering you to expand capabilities and maximize the scientific potential of your experiments.
With UC Enuity’s precise temperature control and an integrated cryo chamber including micromanipulators and cryosphere, ice contamination is minimized. During sample manipulation, micromanipulators and the EM CRION offer stability and flexibility.
Your benefits
Rely on UC Enuity's precise temperature control to maintain optimal cooling conditions for every sample, even in humid conditions.
Ensure reliable and precise sample collection, minimizing the risk of section loss or displacement.
Expand your UC Enuity with the cryochamber to a state-of-the-art cryo sectioning system in just a few minutes.
UC Enuity with cryo chamber for minimized ice contamination.
Reduce fatigue with adaptable ergonomics
UC Enuity prioritizes your comfort by offering adaptable ergonomics for users. You will be able to sit comfortably at UC Enuity, even for time-consuming cryosectioning tasks.
How UC Enuity adapts to you
Easily adapt the system's geometry to accommodate your ergonomic needs.
Adapt the height and angle of the stereo microscope to align with your height and position.
Rest your arms comfortably on cushioned supports for a more ergonomic and user-friendly experience.
UC Enuity adapts to your ergonomic needs
Protect yourself, your samples, and your equipment
Safety comes first with UC Enuity. You can access fluorescence information safely with UV-blocking shields for both room temperature and cryo setups.
With UC Enuity’s enclosed design you will have confidence in safe liquid nitrogen handling that prevents the user from direct exposure.
UC Enuity with cryo chamber and Dewar
Maximize uptime with RemoteCare
Now you can enhance your system's performance with RemoteCare from Leica Microsystems to keep your system running smoothly. Anomalies are detected proactively with UC Enuity, receiving instant notifications for 20+ error codes.
You can also access 30+ critical parameters in real-time for swift issue resolution. Ensure constant monitoring for proactive system maintenance, maximizing your UC Enuity's uptime and streamlining troubleshooting.