Science Lab

Science Lab

Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.

A Guide to Model Organisms in Research

A model organism is a species used by researchers to study specific biological processes. They have similar genetic characteristics to humans and are commonly used in research areas such as genetics,…
Area of a printed circuit board (PCB) which was imaged with extended depth of field (EDOF) using digital microscopy.

Depth of Field in Microscope Images

For microscopy imaging, depth of field is an important parameter when needing sharp images of sample areas with structures having significant changes in depth. In practice, depth of field is…
Pancreatic Ductal Adenocarcinoma with 11 Aerobic Glycolysis/Warburg Effect biomarkers shown – BCAT, Glut1, HK2, HTR2B, LDHA, NaKATPase, PCAD, PCK26, PKM2, SMA1, and Vimentin.

Dive into Pancreatic Cancer Research with Big Data

Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC),…
Colon adenocarcinoma and normal colon at the tumor margin. 13 biomarkers shown including Cadherin, CD3, CD4, CD8, CD20, CD31, CD45, Collagen, Caspase 9, BCL2, Beta-Catenin, Vimentin, and Smooth Muscle Actin.

Uncover the Hidden Complexity of Colon Cancer with Big Data

Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like…
Digital microscopy simplifies documenting cell-culture results electronically while following 21 CFR part 11 guidelines for biopharma.

Introduction to 21 CFR Part 11 for Electronic Records of Cell Culture

This article provides an introduction to the recommendations of 21 CFR Part 11 from the FDA, specifically focusing on the audit trail and user management in the context of cell-culture laboratories.…

A Guide to Darkfield Microscopes

A darkfield microscope offers a way to view the structures of many types of biological specimens in greater contrast without the need of stains.

A Guide to Phase Contrast

A phase contrast light microscope offers a way to view the structures of many types of biological specimens in greater contrast without the need of stains.
TauSTED 775 resolves the intricate cytoskeleton network labeled with SiR-tubulin (glow - Spyrochrome), and trafficking vesicles labeled with CF594 (cyan - Biotium).

A Guide to Super-Resolution

Find out more about Leica super-resolution microscopy solutions and how they can empower you to visualize in fine detail subcellular structures and dynamics.

A Guide to Differential Interference Contrast (DIC)

A DIC microscope is a widefield microscopy which has a polarization filter and Wollaston prism between the light source and condenser lens and also between the objective lens and camera sensor or…
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