Corporate Communications

Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis of microstructures and nanostructures.

We offer scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies.

Follow us

Developing embryos of different species at different stages during the elongation of their posterior body axis, from left to right in developmental time. The labelled regions in red depict a region of undifferentiated cells called the tailbud, with the corresponding region generated from that tissue shaded in grey. Upper row: lamprey; middle row: catshark; bottom row, zebrafish. This figure has been adapted from the following publication: Steventon, B., Duarte, F., Lagadec, R., Mazan, S., Nicolas, J.-F., & Hirsinger, E. (2016). Species tailoured contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates. Development, 2016. 143(10):1732-41

How to Study Gene Regulatory Networks in Embryonic Development

Join Dr. Andrea Boni by attending this on-demand webinar to explore how light-sheet microscopy revolutionizes developmental biology. This advanced imaging technique allows for high-speed, volumetric…

GLP-1 and PYY localized to distinct secretory pools in L-cells.

Cutting-Edge Imaging Techniques for GPCR Signaling

With this webinar on-demand enhance your pharmacological research with our webinar on GPCR signaling and explore cutting-edge imaging techniques that aim to understand how GPCR signaling translates…

Stripe assay performed on a THUNDER Imager Cell. Courtesy of Maria Carrasquero Ordaz, University of Oxford.

Revealing Neuronal Migration’s Molecular Secrets

Different approaches can be used to investigate neuronal migration to their niche in the developing brain. In this webinar, experts from The University of Oxford present the microscopy tools and…

Immunofluorescence image of a mouse enodmetrial organoid stained with CK14 and DAPI

Advancing Uterine Regenerative Therapies with Endometrial Organoids

Prof. Kang's group investigates important factors that determine the uterine microenvironment in which embryo insertion and pregnancy are successfully maintained. They are working to develop new…

Mosaic scan of a Masson-Goldner stained cat brain. Magnification: 20x.

Lipidomics Analysis of Sparse Cells based on Laser Microdissection

Delve into cellular intricacies with high-coverage targeted lipidomics analysis of sparse cells. This advanced method, integrating Laser Microdissection (LMD) and Liquid Chromatography-Mass…

Evolved ARveo 8: Operating Room (OR) set-up.

Augmented Reality: Transforming Neurosurgical Procedures

In this ebook, you will explore the exciting advances that Augmented Reality (AR) brings to the field of neurosurgery. This comprehensive guide, including explanatory videos, addresses key questions…

Laser Microdissection Protocols for Tissue and Cell Isolation - Download free eBook

In this Bio-protocol Selections, we present a collection of open-access, detailed methods papers using LCM to purify and isolate tissues and cells from plants, mouse embryos, cancer cells, neurons,…

Intestinal organoids label with FUCCI reporter to follow cell cycle dynamics. Courtesy of Franziska Moos. Liberali lab. FMI Basel (Switzerland).

Dual-View LightSheet Microscope for Large Multicellular Systems

Visualizing the dynamics of complex multicellular systems is a fundamental goal in biology. To address the challenges of live imaging over large spatiotemporal scales, Franziska Moos et. al. present…

Multicolor fixed STED image. Inner ear section, mouse, TauSTED Xtend 589 on AF488 and TauSTED Xtend 775 on AF633-Phalloidin. Sample courtesy of Dennis Derstrof, Klinik für Hals-, Nasen und Ohrenheilkunde, Universität Marburg & Prof. Dr. Dominik Oliver aus dem Institut für Physiologie und Pathophysiologie, Abteilung für Neurophysiologie, Universität Marburg.

Extended Live-cell Imaging at Nanoscale Resolution

Extended live-cell imaging with TauSTED Xtend. Combined spatial and lifetime information allow super-resolution microscopy at extremely low light dose.

Multicolor TauSTED Xtend 775 for Cell Biology applications that require nanoscopy resolution for multiple cellular components. Cells showing vimentin fibrils (AF 594), actin network (ATTO 647N), and nuclear pore basket (CF 680R). Sample courtesy of Brigitte Bergner, Mariano Gonzales Pisfil, Steffen Dietzel, Core Facility Bioimaging, Biomedical Center, Ludwig-Maximilians-University, Munich, Germany.

The Guide to STED Sample Preparation

This guide is intended to help users optimize sample preparation for stimulated emission depletion (STED) nanoscopy, specifically when using the STED microscope from Leica Microsystems. It gives an…

Accelerating Discovery for Multiplexed Imaging of Diverse Tissues

Explore IBEX: Open-source multiplexed imaging. Join the collaborative IBEX Imaging Community for optimized tissue processing, antibody selection, and human atlas construction.

Spheroid stained with Cyan: Dapi nuclear countertain; Green AF488 Involucrin; Orange AF55 Phalloidin Actin; Magenta AF647 CK14.

Notable AI-based Solutions for Phenotypic Drug Screening

Learn about notable optical microscope solutions for phenotypic drug screening using 3D-cell culture, both planning and execution, from this free, on-demand webinar.

Hepatocellular Carcinoma with 13 biomarkers shown – Beta-Catenin, CD3D, CD4, CD8a, CD31, CD44, CD163, DAPI, PanCK, PCK26, PD1, SMA, and Vimentin.

Understanding Tumor Heterogeneity with Protein Marker Imaging

Explore tumor heterogeneity and immune cell dynamics. See how quantitative imaging analysis reveals spatial relationships and molecular insights crucial for advancing cancer research and therapeutics.

Murine esophageal organoids (DAPI, Integrin26-AF 488, SOX2-AF568) imaged with the THUNDER Imager 3D Cell Culture. Courtesy of Dr. F.T. Arroso Martins, Tamere University, Finland.

How to Get Deeper Insights into your Organoid and Spheroid Models

In this eBook, learn about key considerations for imaging 3D cultures, such as organoids and spheroids, and discover microscopy solutions to shed new insights into dynamic processes in 3D real-time

Esophageal tissue with a squamous cell carcinoma labelled with the 4 biomarkers PanCk, DAPI, NaKATPase, and Vimentin.

Discover how Multiplexed Bioimaging can Advance Cancer Research

Explore multiplexing with up to 60 biomarkers, enabling advanced tumor imaging approaches to gather precise, spatially-resolved single-cell data that helps enhance cancer research and clinical…

Application example of hyperspectral imaging

Potential of Multiplex Confocal Imaging for Cancer Research and Immunology

Explore the new frontiers of multi-color fluorescent imaging: from image acquisition to analysis

Serious Game in Intraoperative Neurosurgery. Image courtesy of Dr. Lucas Troude.

Enhancing Neurosurgery Teaching

Learn about the Serious Game in Intraoperative Neurosurgery and how it supports neurosurgical teaching and the acquisition of decision-making skills.

Acrylonitrile butadiene styrene (ABS) stained with osmium tetroxide (OsO4), sectioned with a DIATOME diamond knife at room temperature, and then imaged with HAADF TEM.

Ultramicrotomy Techniques for Materials Sectioning

Learn about ultramicrotomy for materials sectioning when investigating polymers and brittle materials with transmission (TEM) or scanning electron microscopy (SEM) or atomic force microscopy.

Exploring Subcellular Spatial Phenotypes with SPARCS

Discover spatially resolved CRISPR screening (SPARCS), a platform for microscopy-based genetic screening for spatial subcellular phenotypes at the human genome scale.

Caption: Collaboration is key Picture copyright: Donenko Oleksii, Shutterstock

Launching a Neurosurgical Department with Limited Resources

Learn about Dr. Claire Karekezi’s journey and experience launching a neurosurgical department within the Rwanda Military Hospital with limited resources.

Augmented Reality fluorescence supports each step of neurovascular surgery procedures. Image courtesy of Dr. Christof Renner.

Use of AR Fluorescence in Neurovascular Surgery

Learn about the use of GLOW800 Augmented Reality in neurovascular surgery through clinical cases and videos, including aneurysm and tumor resection cases.

Pancreatic Ductal Adenocarcinoma with 11 Apoptosis biomarkers shown – BAK, BAX, BCL2, BCLXL, Caspase9, CIAP1, NaKATPase, PCK26, SMAC, Vimentin, and XIAP.

Multiplexing with Luke Gammon: Advance your Spatial Biology Research

Learn how multiplexing imaging and spatial biology can help researchers better understand complex biological systems. In this interview, Dr. Gammon and Dr. Pointu of Leica Microsystems discuss pain…

Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM.

Imaging Organoid Models to Investigate Brain Health

Imaging human brain organoid models to study the phenotypes of specialized brain cells called microglia, and the potential applications of these organoid models in health and disease.

In vivo imaging of a mouse pial and cortical vasculature through a glass window (ROSAmT/mG::Pdgfb-CreERT2 mouse meningeal and cortical visualization following tamoxifen induction and craniotomy). Courtesy: Thomas Mathivet, PhD

Windows on Neurovascular Pathologies

Discover how innate immunity can sustain deleterious effects following neurovascular pathologies and the technological developments enabling longitudinal studies into these events.

Lifetime-based multiplexing in live cells using TauSeparation. Mammalian cells expressing LifeAct-GFP (ibidi GmbH) and labelled with MitoTracker Green. Acquisition with one detector, intensity information shown in grey. The two markers can be separated using lifetime information: LifeAct-GFP (cyan), MitoTracker Green (magenta). Image acquired with STELLARIS 5.

The Power of Reproducibility, Collaboration and New Imaging Technologies

In this webinar you willl learn what impacts reproducibility in microscopy, what resources and initiatives there are to improve education and rigor and reproducibility in microscopy and how…

Branched organoid growing in collagen where the Nuclei are labeled blue. To detect the mechanosignaling process, the YAP1 is labeled green.

Examining Developmental Processes In Cancer Organoids

Interview: Prof. Bausch and Dr. Pastucha, Technical University of Munich, discuss using microscopy to study development of organoids, stem cells, and other relevant disease models for biomedical…

Mouse cortical neurons. Transgenic GFP (green). Image courtesy of Prof. Hui Guo, School of Life Sciences, Central South University, China

How Microscopy Helps the Study of Mechanoceptive and Synaptic Pathways

In this podcast, Dr Langenhan explains how microscopy helps his team to study mechanoceptive and synaptic pathways, their challenges, and how they overcome them.

Advanced technologies support neurosurgical teaching. Image courtesy of Dr. Florian Bernard.

3D, AR & VR for Teaching in Neurosurgery

Discover the evolution of neurosurgical teaching and how 3D, Augmented Reality and Virtual Reality can help better learn anatomy and acquire surgical skills.

THY1-EGFP labeled neurons in mouse brain processed using the PEGASOS 2 tissue clearing method, imaged on a Leica confocal microscope. Neurons were traced using Aivia’s 3D Neuron Analysis – FL recipe. Image credit: Hu Zhao, Chinese Institute for Brain Research.

Unlocking Insights in Complex and Dense Neuron Images Guided by AI

The latest advancement in Aivia AI image analysis software provides improved soma detection, additional flexibility in neuron tracing, 3D relational measurement including Sholl analysis and more.

What are the Challenges in Neuroscience Microscopy?

eBook outlining the visualization of the nervous system using different types of microscopy techniques and methods to address questions in neuroscience.