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Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis of microstructures and nanostructures.
We offer scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies.
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A Guide to Cryo-Electron Tomography
Cryo-electron tomography (CryoET) is used to resolve biomolecules within their cellular environment down to an unprecedented resolution below one nanometer.
Simplifying Complex Fluorescence Multiwell Plate Assays
Apoptosis, or programmed cell death, occurs during organism embryo development to eliminate unwanted cells and during healing in adults to rid the body of damaged cells and help prevent cancer.…
Efficient Long-term Time-lapse Microscopy
When doing time-lapse microscopy experiments with spheroids, there are certain challenges which can arise. As the experiments can last for several days, prolonged sample survival must be achieved…
Dr. Tawfik Shares his Expert View on Direct Horizontal Chopping in Cataract Surgery
It is estimated that nearly 28 million cataract surgery procedures are performed worldwide every year. Phacoemulsification is the most common method used to remove the cataract and chopping maneuvers…
Free Flap Procedures in Oncological Reconstructive Surgery
Free flap surgery is considered the gold standard for breast, head and neck reconstructions for cancer patients. These procedures, which enable functional and aesthetic rehabilitation, can be quite…
Minor’s Syndrome Surgical Intervention by Prof. Vincent Darrouzet
Minor’s disease, also called Superior Semicircular Canal Dehiscence (SSCD) or Minor’s syndrome, is a rare disorder of the inner ear that affects hearing and balance. The disease is characterized by…
How to Choose a Microscope for Reconstructive Surgery
Plastic and reconstructive surgery requires excellent visualization to repair intricate and fine structures. Oncological reconstructive surgery procedures are among the most delicate, including breast…
Advances in Oncological Reconstructive Surgery
Decision making and patient care in oncological reconstructive surgery have considerably evolved in recent years. New surgical assistance technologies are helping surgeons push the boundaries of what…
How to Remove Out-Of-Focus Blur and Improve Segmentation Accuracy
The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However,…
Live-Cell Imaging Techniques
The understanding of complex and/or fast cellular dynamics is an important step for exploring biological processes. Therefore, today’s life science research is increasingly focused on dynamic…
The AI-Powered Pixel Classifier
Achieving reproducible results manually requires expertise and is tedious work. But now there is a way to overcome these challenges by speeding up this analysis to extract the real value of the image…
Applying AI and Machine Learning in Microscopy and Image Analysis
Prof. Emma Lundberg is a professor in cell biology proteomics at KTH Royal Institute of Technology, Sweden. She is also the director of the Cell Atlas, an integral part of the Swedish-based Human…
A New Method for Convenient and Efficient Multicolor Imaging
The technique combining hyperspectral unmixing and phasor analysis was developed to simplify the process of getting images from a sample labeled with multiple fluorophores. This aggregate method…
Examining Critical Developmental Events in High-Definition
Extended live cell imaging of embryo development requires a delicate balance between light exposure, temporal resolution and spatial resolution to maintain cells’ viability. Compromises between the…
How to Select a Microscope for Cataract Surgery
What to consider in the selection of an ophthalmic microscope for cataract procedures. Bearing these aspects in mind will equip surgeons well for talks with manufacturer representatives. Many…
Intravital Microscopy of Cancer
Join our guest speaker Prof Dr Jacco van Rheenen, as he presents his work on the identity, behavior and fate of cells that drive the initiation and progression of cancer.
Tracking Single Cells Using Deep Learning
AI-based solutions continue to gain ground in the field of microscopy. From automated object classification to virtual staining, machine and deep learning technologies are powering scientific…
Learning the Cellular Architecture from its Optical Properties
In the last 3 years, microscopists have started to use "AI based" solutions for a wide range of applications, including image acquisition optimization (smart microscopy), object classification, image…
Advancing Cellular Ultrastructure Research
Freeze-fracture and freeze-etching are useful tools for studying flexible membrane-associated structures such as tight junctions or the enteric glycocalyx. Freeze-fracture and etching are two…
Benefits of Combining STED and Lifetime
In this interview, Professor Alberto Diaspro talks about the advantages of the White Light Laser and the TauSTED capabilities of STELLARIS 8 STED. He speaks about his experience with the confocal…
How to use a Surgical Microscope as an Operating Room Nurse
Surgical microscopes play an essential role in the modern microsurgery procedures. It provides the surgeon, assistant and operating room staff with a magnified and illuminated high-quality image of…
Clinical Symposium on OCT-guided Cornea Surgery
In this recording Prof. Mehta from Singapore National Eye Centre and Prof. Fontana from Santa Maria
Nuova Hospital in Regio Emilia, Italy, share their expertise on corneal surgery. They present PK,…
Fluorescence Lifetime-based Imaging Gallery
Confocal microscopy relies on the effective excitation of fluorescence probes and the efficient collection of photons emitted from the fluorescence process. One aspect of fluorescence is the emission…
Optimizing THUNDER Platform for High-Content Slide Scanning
With rising demand for full-tissue imaging and the need for FL signal quantitation in diverse biological specimens, the limits on HC imaging technology are tested, while user trainability and…
Visualizing Protein Degradation and Aggregation in the Living Cell
Our guest speaker, Prof Dr Eric Reits, presents his work on neurodegenerative disorders. Reits’ group are experts on the subject of Huntington’s disease and work towards identifying leads for…
Towards Advanced Use of Intraoperative OCT in Cataract Surgery
In this White Paper, Dr. Rachid Tahiri shares his personal experience with the Leica EnFocus intraoperative OCT, the valuable features supporting smooth surgery and how it allows him to minimize…
How Clinical and Surgical Microscopes Support Otolaryngology
The number of ENT surgery procedures is increasing year after year. It is estimated that there will be over 21 million ENT procedures performed annually worldwide by 2022.
Dr. Duane Mol is the…
Life Beyond the Pixels: Deep Learning Methods for Single Cell Analysis
Our guest speaker Prof Dr Peter Horvath presents his work on single cell-based large-scale microscopy experiments. This novel targeting approach includes the use of machine learning models and…
Physiology Image Gallery
Physiology is about the processes and functions within a living organism. Research in physiology focuses on the activities and functions of an organism’s organs, tissues, or cells, including the…
Live Cell Imaging Gallery
Live cell microscopy techniques are fundamental to get a better understanding of cellular and molecular function. Today, widefield microscopy is the most common technique used to visualize cell…
