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Jan Schumacher , Dr.

Software Manager, Leica Microsystems CMS GmbH.

Jan joined Leica Microsystems in 2014 as an Application Manager responsible for neuroscience applications of widefield microscopy. In 2017, he became part of the product management team for LAS X software intended for widefield microscopy applied to the life sciences.  He switched into Leica Microsystems’ sales organization as an Advanced Workflow Specialist in 2019.

Prior to joining Leica Microsystems, Jan was involved in acupuncture research using electrophysiological techniques. For his PhD work done at the Max Planck Institute (MPI) for Biophysics in Frankfurt, Germany, he utilized various in vivo imaging techniques to investigate the sense of smell.

Mouse retina was fixed and stained by following reagents: anti-CD31 antibody (green): Endothelia cells, IsoB4 (red): Blood vessels, and microglia anti-GFAP antibody (blue): Astrocytes Sample courtesy by Jeremy Burton, PhD and Jiyeon Lee, PhD, Genentech Inc., South San Francisco, USA. Imaged by Olga Davydenko, PhD (Leica). Imaged with a THUNDER Imager 3D Cell Culture.

An Introduction to Computational Clearing

Many software packages include background subtraction algorithms to enhance the contrast of features in the image by reducing background noise. The most common methods used to remove background noise…

Crystal Clear Cryo Light-microscopy Images

This article describes how computational clearing of cryo light microscopy images improves the identification of cellular targets for cryo electron-microscopy.
HeLa cell spheroid stained with Alexa Fluor 568 Phalloidin (Actin) and YOYO 1 iodide (Nucleus).

Real Time Images of 3D Specimens with Sharp Contrast Free of Haze

THUNDER Imagers deliver in real time images of 3D specimens with sharp contrast, free of the haze or out-of-focus blur typical of widefield systems. They can even image clearly places deep inside a…
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