Michael Smith , Ph.D.
Michael Smith, Ph.D. is Application Manager for the Cell DIVE Multiplexed Imaging Solution at Leica Microsystems. He completed a Ph.D. in the genetics of DNA repair at Columbia University and a postdoctoral fellowship in genome integrity and cellular aging at Memorial Sloan Kettering Cancer Center, where he leveraged microscopy to understand the real-time dynamics of DNA homeostasis. His passion for answering biological questions using imaging technologies led him to his current position, where he provides technical expertise and customer support for the Cell DIVE platform.
Probing Human Alzheimer's Cortical Section using Spatial Multiplexing
Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by the progressive decline of cognitive function. Spatial profiling of AD brain may reveal cellular…
Empowering Spatial Biology with Open Multiplexing and Cell DIVE
Spatial biology and multiplexed imaging workflows have become important in immuno-oncology research. Many researchers struggle with study efficiency, even with effective tools and protocols. Here, we…
AI-Powered Multiplexed Image Analysis to Explore Colon Adenocarcinoma
In this application note, we demonstrate a spatial biology workflow via an AI-powered multiplexed image analysis-based exploration of the tumor immune microenvironment in colon adenocarcinoma.
A Meta-cancer Analysis of the Tumor Spatial Microenvironment
Learn how clustering analysis of Cell DIVE datasets in Aivia can be used to understand tissue-specific and pan-cancer mechanisms of cancer progression
IBEX, Cell DIVE, and RNA-Seq: A Multi-omics Approach to Follicular Lymphoma
In a recent study by Radtke et al., a multi-omics spatial biology approach helps shed light on early relapsing lymphoma patients
Spatial Biology: Learning the Landscape
Spatial Biology: Understanding the organization and interaction of molecules, cells, and tissues in their native spatial context
Complex Made Simple: Antibodies in Multiplexed Imaging
Build panels, plan studies, and get the most from precious reagents using this antibody multiplexing guide from Leica Microsystems
Multiplexed Imaging Types, Benefits and Applications
Multiplexed imaging is an emerging and exciting way to extract information from human tissue samples by visualizing many more biomarkers than traditional microscopy. By observing many biomarkers…
