Leica Microsystems
Leica Microsystems is a world leader in microscopes and scientific instruments. Founded as a family business in the nineteenth century, the company’s history was marked by unparalleled innovation on its way to becoming a global enterprise.
Its historically close cooperation with the scientific community is the key to Leica Microsystems’ tradition of innovation, which draws on users’ ideas and creates solutions tailored to their requirements. At the global level, Leica Microsystems is organized in three divisions, all of which are among the leaders in their respective fields: Life Science, Industry and Medical.
The company is represented in over 100 countries with 6 manufacturing facilities in 5 countries, sales and service organizations in 20 countries, and an international network of dealers. The company is headquartered in Wetzlar, Germany.
Following Multiple Events during Staurosporine Apoptosis
In this video on demand, we show how adding additional markers to an apoptosis kit can markedly increase the amount of information a researcher can obtain from the same experiment. The simultaneous…
Deep Visual Proteomics Provides Precise Spatial Proteomic Information
Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance…
RNA Quality after Different Tissue Sample Preparation
The influence of sample preparation and ultraviolet (UV) laser microdissection (UV LMD) on the quality of RNA from murine-brain tissue cryo-sections is described in this article. To obtain good…
Digitalization in Neurosurgical Planning and Procedures
Learn about Augmented Reality, Virtual Reality and Mixed Reality in neurosurgery and how they can help overcome challenges.
Factors to Consider for a Cleanliness Analysis Solution
Choosing the right cleanliness analysis solution is important for optimal quality control. This article discusses the important factors that should be taken into account to find the solution that best…
New Imaging Tools for Cryo-Light Microscopy
New cryo-light microscopy techniques like LIGHTNING and TauSense fluorescence lifetime-based tools reveal structures for cryo-electron microscopy.
A Guide to Fluorescence Lifetime Imaging Microscopy (FLIM)
The fluorescence lifetime is a measure of how long a fluorophore remains on average in its excited state before returning to the ground state by emitting a fluorescence photon.
H&E Staining in Microscopy
If we consider the role of microscopy in pathologists’ daily routines, we often think of the diagnosis. While microscopes indeed play a crucial role at this stage of the pathology lab workflow, they…
Golgi Organizational Changes in Response to Cell Stress
In this video on demand, our special guest George Galea from EMBL Heidelberg will look at HeLa Kyoto cells treated with various chemotherapeutic agents to investigate their effect on the Golgi complex…
Cleanliness Analysis for Particulate Contamination
Devices, products, and their components fabricated in many industries can be quite sensitive to contamination and, as a result, have stringent requirements for technical cleanliness. Measurement…
Efficient Particle Counting and Analysis
This report discusses particle counting and analysis using optical microscopy for cleanliness of parts and components. Particle counting and analysis is a critical part of quality assurance in the…
AI-Enabled Spatial Analysis of Complex 3D Datasets
This video on demand offers practical advice on the extraction of publication grade insights from microscopy images. Our special guest Luciano Lucas (Leica Microsystems) will illustrate how Mica’s…
Quality Control Under the Microscope
Fast-rising demand for electric vehicles is one of the market’s main drivers, but there are other hotspots of growth, including the rise in renewable energy installations, such as photovoltaic panels,…
Multiplexed Imaging Types, Benefits and Applications
Multiplexed imaging is an emerging and exciting way to extract information from human tissue samples by visualizing many more biomarkers than traditional microscopy. By observing many biomarkers…
3D Tissue Imaging: From Fast Overview To High Resolution With One Click
3D Tissue imaging is a widespread discipline in the life sciences. Researchers use it to reveal detailed information of tissue composition and integrity, to make conclusions from experimental…
How To Perform Fast & Stable Multicolor Live-Cell Imaging
With the help of live-cell imaging researchers gain insights into dynamic processes of living cells up to whole organisms. This includes intracellular as well as intercellular activities. Protein or…
Imaging of Cardiac Tissue Regeneration in Zebrafish
Learn how to image cardiac tissue regeneration in zebrafish focusing on cell proliferation and response during recovery with Laura Peces-Barba Castaño from the Max Planck Institute.
Hydraulics in the Automotive and Aerospace Industries
Cleanliness standards relating to lubricants, hydraulic fluids, and oils, e.g., ISO 4406 and DIN 51455 are discussed in this article. Cleanliness plays a central role in the automotive and…
TauInteraction – Studying Molecular Interactions with TauSense
Fluorescence microscopy constitutes one of the pillars in life sciences and is a tool commonly used to unveil cellular structure and function. A key advantage of fluorescence microscopy resides in the…
Studying Wound Healing of Smooth Muscle Cells
This article discusses how wound healing of cultured smooth muscle cells (SMCs) in multiwell plates can be reliably studied over time with less effort using a specially configured Leica inverted…
Cleanliness of Automotive Components and Parts
This article discusses the ISO 16232 standard and VDA 19 guidelines and briefly summarizes the particle analysis methods. They give important criteria for the cleanliness of automotive parts and…
How Does The Cytoskeleton Transport Molecules?
VIDEO ON DEMAND - See how 3D cysts derived from MDCK cells help scientists understand how proteins are transported and recycled in tissues and the role of the cytoskeleton in this transport.
Studying Early Phase Development of Zebrafish Embryos
This video on demand focuses on combining widefield and confocal imaging to study the early-stage development of zebrafish embryos (Danio rerio), from oocyte to multicellular stage.
Multi-Color Caspase 3/7 Assays with Mica
Caspases are involved in apoptosis and can be utilized to determine if cells are undergoing this programmed cell death pathway in so-called caspase assays. These assays can be run by e.g. flow…
How To Get Multi Label Experiment Data With Full Spatiotemporal Correlation
This video on demand focuses on the special challenges of live cell experiments. Our hosts Lynne Turnbull and Oliver Schlicker use the example of studying the mitochondrial activity of live cells.…
Create New Options for Live Cell Imaging
The use of state-of-the-art AI systems is pushing image analysis into a new generation. Challenges like the conflict between imaging power and sample integrity are being overcome with THUNDER’s…
Fast, High-contrast 3D Imaging of Sensory Neurons
This article discusses how fast, high-contrast 3D imaging of dorsal root ganglion (DRG) tissue with a THUNDER Imager Tissue using large volume computational clearing (LVCC) allows sensory neurons to…
Find Relevant Specimen Details from Overviews
Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
AI Microscopy Image Analysis – An Introduction
Artificial intelligence-guided microscopy image analysis and visualization is a powerful tool for data-driven scientific discovery. AI can help researchers tackle challenging imaging applications,…
How to Target Fluorescent Structures in 3D for Cryo-FIB Milling
This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in…
