Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.

How to Conduct Standard-Compliant Analysis of Non-Metallic Inclusions in Steel

This webinar will provide an overview of the significance of non-metallic inclusions in steel and outline the important global standards for rating the quality of steel and difficulties that arise in…

Oncological Maxillofacial Reconstructive Surgery at the Paris Saint-Joseph Hospital with Dr. Benichou. The Leica M530 OHX microscope is used by plastic surgeons in a comfortable standing up position.

Plastic & Reconstructive Surgery: Why Use a Microscope

Plastic and Reconstructive Surgery procedures can be delicate. Visualization solutions play an essential role, allowing to perform the surgery in the best conditions. And more and more plastic…

Minimally Invasive Spine Surgery: Improving Precision and Accuracy with Microscopes

Spine surgery is extremely delicate and requires extensive training and experience. Innovative visualization technologies can also help achieve better outcomes allowing to see more and have a clearer…

Neurosurgery with Heads-up Display

In the following video interviews Prof. Dr. Raphael Guzman, Vice Chairman of the Department of Neurosurgery at the University Hospital in Basel, Switzerland, talks about his experience in heads-up…

Workflows and Instrumentation for Cryo-electron Microscopy

Cryo-electron microscopy is an increasingly popular modality to study the structures of macromolecular complexes and has enabled numerous new insights in cell biology. In recent years, cryo-electron…

Mouse retina was fixed and stained by following reagents: anti-CD31 antibody (green): Endothelia cells, IsoB4 (red): Blood vessels, and microglia anti-GFAP antibody (blue): Astrocytes Sample courtesy by Jeremy Burton, PhD and Jiyeon Lee, PhD, Genentech Inc., South San Francisco, USA. Imaged by Olga Davydenko, PhD (Leica). Imaged with a THUNDER Imager 3D Cell Culture.

An Introduction to Computational Clearing

Many software packages include background subtraction algorithms to enhance the contrast of features in the image by reducing background noise. The most common methods used to remove background noise…

Factors to Consider When Selecting a Research Microscope

An optical microscope is often one of the central devices in a life-science research lab. It can be used for various applications which shed light on many scientific questions. Thereby the…

Challenges Faced When Manually Rating Non-Metallic Inclusions (NMIs) to Determine Steel Quality

Rapid, accurate, and reliable rating of non-metallic inclusions (NMIs) is instrumental for the determination of steel quality. This article describes the challenges that arise from manual NMI rating,…

Influenca in lung epithelial cells (porcine) - THUNDER Imager 3D Cell Culture Influenca virus – red, cilia – green, Nuclei – blue.

How Can Immunofluorescence Aid Virology Research?

Modern virology research has become as crucial now as ever before due to the global COVID-19 pandemic. There are many powerful technologies and assays that virologists can apply to their research into…