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Probing Human Alzheimer's Cortical Section using Spatial Multiplexing

Enhancing our understanding of the spatial heterogeneity in human Alzheimer’s cortical section by combining multiplexed imaging and AI-guided image analysis

Multiplexed Cell DIVE imaging to characterize the spatial landscape in Human Alzheimer’s Cortical Tissue Human_Alzheimers_Cortical_Tissue_Multiplexed_Cell_DIVE_imaging.jpg

Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by the progressive decline of cognitive function. Spatial profiling of AD brain may reveal cellular relationships, facilitating a better understanding of disease etiology. This study captures a global overview of the AD cortical tissue composition and emphasizes the streamlined workflow of Cell DIVE imaging, from data acquisition to AI-based analysis using Aivia software, resulting in quicker insights.

Key learnings:

  • Investigate the spatial distribution of AD-associated markers (e.g., the aggregation patterns of Tau proteins and β -amyloid plaques) throughout the cortical tissue of the brain. 
  • Characterize the neuronal loss by identifying cell types affected by neurodegeneration in AD cortical tissue.
  • Explore the spatial landscape of neuroinflammation by visualizing microglia and astrocytes relative to the B-amyloid plaques.
  • Discover the benefits of transforming tissue research with the Cell DIVE multiplex imaging solution and AI-powered image analysis using Aivia.

In this study, we demonstrate multiplexed Cell DIVE imaging using a novel CST® panel to probe AD cortical tissue section. Further, using AI-guided analysis with AIVIA provides the researcher the power to-characterize individual neuronal components and identify spatially co-localized populations of neuronal cell types with respect to β -amyloid plaques using clustering and relational analysis. 

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