Probing Human Alzheimer's Cortical Section using Spatial Multiplexing

Key learnings:

• Investigate the spatial distribution of AD-associated markers (e.g., the aggregation patterns of Tau proteins and β -amyloid plaques) throughout the cortical tissue of the brain. 
• Characterize the neuronal loss by identifying cell types affected by neurodegeneration in AD cortical tissue.
• Explore the spatial landscape of neuroinflammation by visualizing microglia and astrocytes relative to the B-amyloid plaques.
• Discover the benefits of transforming tissue research with the Cell DIVE multiplex imaging solution and AI-powered image analysis using Aivia.

In this study, we demonstrate multiplexed Cell DIVE imaging using a novel CST® panel to probe AD cortical tissue section. Further, using AI-guided analysis with AIVIA provides the researcher the power to-characterize individual neuronal components and identify spatially co-localized populations of neuronal cell types with respect to β -amyloid plaques using clustering and relational analysis.