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The Potential of Coherent Raman Scattering Microscopy at a Glance

STELLARIS 8 CRS: a true multi-modal optical discovery instrument for label-free, chemically specific imaging

Multi-color SRS image of a tri-cellular cancer spheroid Tricellular_Cancer_Model.jpg

Coherent Raman scattering microscopy (CRS) is a powerful approach for label-free, chemically specific imaging. It is based on the characteristic intrinsic vibrational contrast of molecules in the sample.

CRS provides high-resolution (sub-cellular level) and dynamic (up to video rate) information on the biochemical composition and metabolic processes in cells, tissues, and intact model organisms. It also enables imaging of small molecules without perturbing their function. This information is highly synergistic with the molecular contrast provided by fluorescence microscopy. Unsurprisingly, CRS is finding a growing number of applications in fields like neurodegenerative disease, cancer, 3D biology, stem cell and developmental biology, and pharmacology.

A true multi-modal optical discovery platform

The STELLARIS 8 CRS coherent Raman scattering microscope offers the two popular CRS modalities – Stimulated Raman Scattering (SRS) and Coherent anti-Stokes Raman Scattering (CARS) – and allows for the simultaneous acquisition of two-photon fluorescence and second-harmonic generation signals. The seamless integration of CRS with the STELLARIS confocal fluorescence microscopy platform results in a true multi-modal optical discovery platform that is capable of capturing a unique combination of biochemical, biophysical, and molecular contrasts.

5-minute overview of the benefits of label-free chemical imaging with the STELLARIS 8 CRS for life science research

5-minutes of background information on the CRS technique and the hands-free standalone STELLARIS 8 CRS solution

Multi-color SRS image of a tri-cellular cancer spheroid

Multi-color SRS image of a tri-cellular cancer spheroid
Multi-color SRS image of a tri-cellular cancer spheroid showing total lipids (yellow, 2850 cm-1), unsaturated lipids (magenta, 3050 cm-1), and collagen (SHG, cyan). Scale bar is 100 μm. Sample courtesy of Rüdiger Rudolf, Julia Klicks, Hochschule Mannheim, Germany.

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