Unlocking the Secrets of Organoid Models in Biomedical Research

Key webinar learnings:

• Examining 3D human bladder microtissue infected with E.coli: Jennifer Rohn's lab at UCL has developed a pioneering 3D human urothelium organoid model (3D-UHU) to explore UTI pathology and treatment failures. Discover how clearer insights provided by the new THUNDER Imager Cell Spinning Disk can help them further explore the impact of bacterial filamentation and intracellular bacterial communities on UTI outcomes.
• Exploring human stem cell-derived mid brain organoids: The Wade-Martins group in Oxford examines disease mechanisms for Parkinson’s disease. See how they develop ventral mid-brain organoids and Enteric Nervous System (Gut-Brain axis) using stem cells and microfluidics and how much more detail they can now uncover.
• How microtubule dynamics influence cell shape: To illustrate the diversity of samples that can benefit from the synergy of THUNDER and spinning disk, we’ll also share data on individual microtubule dynamics, courtesy of the Sainsbury Laboratory in Cambridge.

While spinning disk alone provides fast, versatile, confocal imaging and powerful optical sectioning, the synergistic pairing with THUNDER eliminates residual out-of-focus light, resulting in greater contrast and resolution.

This enables you to extract more statistically significant data from diverse 3D samples in less time and with reduced phototoxicity.

Typical applications include live cells, 3D cell cultures, organoids, spheroids, model organisms, plant biology and thick tissue samples.