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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![](/fileadmin/_processed_/d/e/csm_How_to_Prepare_and_Analyse_Battery_Samples_with_Electron_Microscopy_teaser_8b1d4d5686.jpg)
How to Prepare and Analyse Battery Samples with Electron Microscopy
This workshop covers the sample preparation process for lithium and novel battery sample analysis, as well as other semiconductor samples requiring high-resolution cross-section imaging.
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![The intraoperative OCT showed the ellipsoid had separated from the inner retina with focal attachment to the retinal pigment epithelium (RPE). Images provided by Mr. Robert Henderson The intraoperative OCT showed the ellipsoid had separated from the inner retina with focal attachment to the retinal pigment epithelium (RPE). Images provided by Mr. Robert Henderson](/fileadmin/_processed_/d/b/csm_Ellipsoid_separated_from_the_inner_retina_with_focal_attachment_to_the_retinal_pigment_epithelium_8db22ce4da.jpg)
Utility of Intraoperative OCT in Sub-Retinal Gene Therapy
Discover a case study on the use of intraoperative OCT for pediatric gene therapy and how it supports bleb placement and verifying the foveal contour.
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![Cancer cells Cancer cells](/fileadmin/_processed_/6/b/csm_Cancer_cells_0188d06359.jpg)
The Role of Iron Metabolism in Cancer Progression
Iron metabolism plays a role in cancer development and progression, and modulates the immune response. Understanding how iron influences cancer and the immune system can aid the development of new…
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![Pancreatic Ductal Adenocarcinoma with 5 biomarkers shown – SMA, PanCK PCK26, PanCK AE1, Vimentin, and Glut1. Pancreatic Ductal Adenocarcinoma with 5 biomarkers shown – SMA, PanCK PCK26, PanCK AE1, Vimentin, and Glut1.](/fileadmin/_processed_/3/a/csm_Pancreatic_Ductal_Adenocarcinoma_with_5_biomarkers_7ea537ecff.jpg)
Dig Deeper Into the Complexities of Pancreatic Cancer with Multiplex Imaging
Cell DIVE is an iterative staining workflow for multiplexed imaging that unveils biological pathways to dig deeper into the complexities of pancreatic cancer.
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![Raw widefield and THUNDER image of calcium transients in Drosophila embryos. Courtesy A. Carreira-Rosario, Clandinin laboratory, California, USA. Raw widefield and THUNDER image of calcium transients in Drosophila embryos. Courtesy A. Carreira-Rosario, Clandinin laboratory, California, USA.](/fileadmin/_processed_/7/6/csm_Calcium_transients_in_Drosophila_embryos_teaser_fcd31bd78f.jpg)
Central Nervous System (CNS) Development and Activity in Organisms
This article shows how studying central nervous system (CNS) development in Drosophila-melanogaster embryos expressing a GCaMP calcium indicator in the neurons can be improved with a THUNDER Imager.
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![How is microscopy used in spatial biology? A microscopy guide. How is microscopy used in spatial biology - Teaserimage](/fileadmin/_processed_/0/f/csm_spatial-biology-ebook-tease_5ac6218fa3.jpg)
How is Microscopy Used in Spatial Biology? A Microscopy Guide
Different spatial biology methods in microscopy, such as multiplex imaging, are helping to better understand tissue landscapes. Learn more in this microscopy guide.
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![Cell DIVE Multiplex Imaging Solution Cell DIVE Multiplex Imaging Solution](/fileadmin/_processed_/0/6/csm_Cell_DIVE_acb4a88ab9.jpg)
Complex Made Simple: Antibodies in Multiplexed Imaging
Build panels, plan studies, and get the most from precious reagents using this antibody multiplexing guide from Leica Microsystems
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![Patch pipette touching a murine hippocampal neuron. Image courtesy of A. Aguado, Ruhr University Bochum, Germany. Patch pipette touching a murine hippocampal neuron. Image courtesy of A. Aguado, Ruhr University Bochum, Germany.](/fileadmin/_processed_/c/0/csm_Murine_hippocampal_neuron_with_patch_pipette_8d36fd1763.jpg)
What is the Patch-Clamp Technique?
This article gives an introduction to the patch-clamp technique and how it is used to study the physiology of ion channels for neuroscience and other life-science fields.
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![Neurons imaged with DIC contrast. Neurons imaged with DIC contrast.](/fileadmin/_processed_/3/1/csm_Neurons_imaged_in_DIC_abb6a3742b.jpg)
Differential Interference Contrast (DIC) Microscopy
This article demonstrates how differential interference contrast (DIC) can be actually better than brightfield illumination when using microscopy to image unstained biological specimens.