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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![Material sample with a large height, size, and weight being observed with an inverted microscope. Material sample with a large height, size, and weight being observed with an inverted microscope.](/fileadmin/_processed_/f/4/csm_Inverted_microscope_with_large_sample_crop_04c3257c81.jpg)
Five Inverted-Microscope Advantages for Industrial Applications
With inverted microscopes, you look at samples from below since their optics are placed under the sample, with upright microscopes you look at samples from above. Traditionally, inverted microscopes…
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![Application example of hyperspectral imaging Application example of hyperspectral imaging](/fileadmin/_processed_/9/c/csm_TNBC_LeGO_primary_tumor_db08add779.jpg)
Potential of Multiplex Confocal Imaging for Cancer Research and Immunology
Explore the new frontiers of multi-color fluorescent imaging: from image acquisition to analysis
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![Keratoplasty of pathologic cornea Keratoplasty of pathologic cornea](/fileadmin/_processed_/6/d/csm_Pathologic_cornea_cb99c6735b.jpg)
Intraoperative OCT-Assisted Corneal Transplant Procedures
Learn about the use of intraoperative optical coherence tomography in corneal transplantation and how it facilitates the adaptation of the donor cornea.
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![Serious Game in Intraoperative Neurosurgery. Image courtesy of Dr. Lucas Troude. Serious Game in Intraoperative Neurosurgery. Image courtesy of Dr. Lucas Troude.](/fileadmin/_processed_/b/3/csm_Serious_Game_in_Intraoperative_Neurosurgery_961ca33432.jpg)
Enhancing Neurosurgery Teaching
Learn about the Serious Game in Intraoperative Neurosurgery and how it supports neurosurgical teaching and the acquisition of decision-making skills.
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![Acrylonitrile butadiene styrene (ABS) stained with osmium tetroxide (OsO4), sectioned with a DIATOME diamond knife at room temperature, and then imaged with HAADF TEM. Acrylonitrile butadiene styrene (ABS) stained with osmium tetroxide (OsO4), sectioned with a DIATOME diamond knife at room temperature, and then imaged with HAADF TEM.](/fileadmin/_processed_/a/b/csm_ABS_stained_with_OsO4_and_sectioned_with_a_DIATOME_diamond_knife_66be7f4863.jpg)
Ultramicrotomy Techniques for Materials Sectioning
Learn about ultramicrotomy for materials sectioning when investigating polymers and brittle materials with transmission (TEM) or scanning electron microscopy (SEM) or atomic force microscopy.
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![Single cell datasets Single cell datasets](/fileadmin/_processed_/8/8/csm_Single_cell_datasets_SPARCS_441a58445d.jpg)
Exploring Subcellular Spatial Phenotypes with SPARCS
Discover spatially resolved CRISPR screening (SPARCS), a platform for microscopy-based genetic screening for spatial subcellular phenotypes at the human genome scale.
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![Dr. Ozana Moraru shares two primary open-angle glaucoma cases in which trabeculectomy bleb needling was performed using the Leica M844 microscope with EnFocus intraoperative OCT. Image courtesy of Dr. Ozana Moraru. Dr. Ozana Moraru shares two primary open-angle glaucoma cases in which trabeculectomy bleb needling was performed using the Leica M844 microscope with EnFocus intraoperative OCT. Image courtesy of Dr. Ozana Moraru.](/fileadmin/_processed_/1/0/csm_Trabeculectomy_bleb_needling_performed_with_Leica_M844_microscope_with_EnFocus_intraoperative_OCT_81e3cbbf3e.jpg)
How Intraoperative OCT Helps Gain Greater Insight in Glaucoma Surgery
Learn about the use of intraoperative Optical Coherence Tomography in glaucoma surgery and how it helps see subsurface tissue details.
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![Intraoperative OCT-assisted complex cataract surgery. Image courtesy of Dr. Ozana Moraru. Intraoperative OCT-assisted complex cataract surgery. Image courtesy of Dr. Ozana Moraru.](/fileadmin/_processed_/8/2/csm_Secondary_IOL_implantation_in_a_transplanted_eye_01_cec4f79bdb.jpg)
Ophthalmology: Visualization in Complex Cataract Surgery
Learn about the use of intraoperative Optical Coherence Tomography in cataract surgery and how it supports both standard and complex cataract surgery cases.
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![Molecular structure of the green fluorescent protein (GFP) Molecular structure of the green fluorescent protein (GFP)](/fileadmin/_processed_/a/c/csm_Fluorescent-Proteins_363bb930f2.jpg)
Introduction to Fluorescent Proteins
Overview of fluorescent proteins (FPs) from, red (RFP) to green (GFP) and blue (BFP), with a table showing their relevant spectral characteristics.