Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

A Guide to Darkfield Microscopes

A darkfield microscope offers a way to view the structures of many types of biological specimens in greater contrast without the need of stains.

A Guide to Phase Contrast

A phase contrast light microscope offers a way to view the structures of many types of biological specimens in greater contrast without the need of stains.

A Guide to Super-Resolution

Find out more about Leica super-resolution microscopy solutions and how they can empower you to visualize in fine detail subcellular structures and dynamics.

A Guide to Differential Interference Contrast (DIC)

A DIC microscope is a widefield microscopy which has a polarization filter and Wollaston prism between the light source and condenser lens and also between the objective lens and camera sensor or…
Leica photomanipulation

A Guide to Photomanipulation

The term photomanipulation encompasses a range of techniques that utilize the properties of fluorescent molecules to initiate events and observe how dynamic complexes behave over time in living cells.…
Blood vessel system of a zebrafish larvae

Overcoming Challenges with Microscopy when Imaging Moving Zebrafish Larvae

Zebrafish is a valuable model organism with many beneficial traits. However, imaging a full organism poses challenges as it is not stationary. Here, this case study shows how zebrafish larvae can be…

Selecting the Right Dissecting Microscope

You can spend many hours looking through the eyepieces of a dissecting microscope whenever dissections must be done. Leica Microsystems lets you select from a diverse array of microscopes and…

A Guide to Neuroscience Research

Are you working towards a better understanding of neurodegenerative diseases or studying the function of the nervous system? See how you can make breakthroughs with imaging solutions from Leica…
Cell DIVE multiplexed image of FFPE tissue section from syngeneic murine cancer model, 4T1.

Mapping Tumor Immune Landscape with AI-Powered Spatial Proteomics

Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying…
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