Leica Microsystems: Leica Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Rapid and Reliable Examination of PCBs & PCBAs with Digital Microscopy

Digital microscopes provide users with a convenient and rapid way to acquire high-quality, reliable image data and make quick inspection and analysis of printed circuit boards (PCBs) and assemblies…

In vivo imaging of a mouse pial and cortical vasculature through a glass window (ROSAmT/mG::Pdgfb-CreERT2 mouse meningeal and cortical visualization following tamoxifen induction and craniotomy). Courtesy: Thomas Mathivet, PhD

Windows on Neurovascular Pathologies

Discover how innate immunity can sustain deleterious effects following neurovascular pathologies and the technological developments enabling longitudinal studies into these events.

Corneal transplantation. Image courtesy of Mr. David Anderson.

Ophthalmology Case Study: Corneal Transplantation

Learn about the use of intraoperative Optical Coherence Tomography in Corneal Transplantation and how it helps achieve correct positioning of donor tissue.

The principle of the FusionOptics technology: Of the two separate beam paths (1), one provides depth of field (2) and the other high resolution (3). In the brain, the two images of the sample are merged into a single, optimal 3D image (4).

What is the FusionOptics Technology?

Leica stereo microscopes with FusionOptics provide optimal 3D perception. The brain merges two images, one with large depth of field and the other with high resolution, into one 3D image.

Strain from using a microscope can lead to musculoskeletal pain.

Microscope Ergonomics

This article explains microscope ergonomics and how it helps users work in comfort, enabling consistency and efficiency. Learn how to set up the workplace to keep good posture when using a microscope.

Lifetime-based multiplexing in live cells using TauSeparation. Mammalian cells expressing LifeAct-GFP (ibidi GmbH) and labelled with MitoTracker Green. Acquisition with one detector, intensity information shown in grey. The two markers can be separated using lifetime information: LifeAct-GFP (cyan), MitoTracker Green (magenta). Image acquired with STELLARIS 5.

The Power of Reproducibility, Collaboration and New Imaging Technologies

In this webinar you willl learn what impacts reproducibility in microscopy, what resources and initiatives there are to improve education and rigor and reproducibility in microscopy and how…

Branched organoid growing in collagen where the Nuclei are labeled blue. To detect the mechanosignaling process, the YAP1 is labeled green.

Examining Developmental Processes In Cancer Organoids

Interview: Prof. Bausch and Dr. Pastucha, Technical University of Munich, discuss using microscopy to study development of organoids, stem cells, and other relevant disease models for biomedical…

Mouse cortical neurons. Transgenic GFP (green). Image courtesy of Prof. Hui Guo, School of Life Sciences, Central South University, China

How Microscopy Helps the Study of Mechanoceptive and Synaptic Pathways

In this podcast, Dr Langenhan explains how microscopy helps his team to study mechanoceptive and synaptic pathways, their challenges, and how they overcome them.

Advanced technologies support neurosurgical teaching. Image courtesy of Dr. Florian Bernard.

3D, AR & VR for Teaching in Neurosurgery

Discover the evolution of neurosurgical teaching and how 3D, Augmented Reality and Virtual Reality can help better learn anatomy and acquire surgical skills.