![Science Lab](/fileadmin/_processed_/6/0/csm_lms-sl-header_d2c38d8093.jpg)
Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
Filter articles
Tags
Story Type
Products
Loading...
![](/fileadmin/academy/user_upload/Visualizing-protein-protein.jpg)
Visualizing Protein-Protein Interactions by Non-Fitting and Easy FRET-FLIM Approaches
The Webinar with Dr. Sergi Padilla-Parra is about visualizing protein-protein interaction. He gives insight into non-fitting and easy FRET-FLIM approaches.
Loading...
![Living HeLa cells stained with WGA-488 (yellow), SPY-Actin (cyan), and SiR-Tubulin (magenta). Instant Computational Clearing (ICC) was applied. Living HeLa cells stained with WGA-488 (yellow), SPY-Actin (cyan), and SiR-Tubulin (magenta). Instant Computational Clearing (ICC) was applied.](/fileadmin/_processed_/b/0/csm_Living_HeLa_cells_Instant_Computational_Clearing_e2a2820021.jpg)
How to Perform Dynamic Multicolor Time-Lapse Imaging
Live-cell imaging sheds light on diverse cellular events. As many of these events have fast dynamics, the microscope imaging system must be fast enough to record every detail. One major advantage of…
Loading...
![Spectral separation of 11 fluorophores coupled to polystyrene beads on a STELLARIS confocal system. Spectral separation of 11 fluorophores coupled to polystyrene beads on a STELLARIS confocal system.](/fileadmin/_processed_/f/b/csm_Spectral_separation_of_11_fluorophores_coupled_to_polystyrene_beads_ce1a177fa6.jpg)
Multiplexing through Spectral Separation of 11 Colors
Fluorescence microscopy is a fundamental tool for life science research that has evolved and matured together with the development of multicolor labeling strategies in cells tissues and model…
Loading...
![](/fileadmin/_processed_/b/8/csm_Particulate_contamination_in_between_moving_metal_plates_3543ece773.jpg)
3 Factors Determine the Damage Potential of Particles
This article discusses the 3 factors for determining the potential of a particle to cause damage to parts and components in the automotive and electronic industry. These factors include the…
Loading...
![Skull base tumor removal. Image courtesy of Prof. Pierre-Hugues Roche. Skull base tumor removal. Image courtesy of Prof. Pierre-Hugues Roche.](/fileadmin/_processed_/0/6/csm_Skull_base_tumor_removal_Teaser_21ba8d5be0.jpg)
Skull Base Neurosurgery: Epidural Lateral Approaches
Surgery of skull base tumors and diseases, such as cavernomas, epidermoid cysts, meningiomas and schwannomas, can be quite complex. During the Leica 2021 Neurovisualization Summit, a unique event…
Loading...
![Raw widefield and THUNDER image of transversal mouse adult fiber lens section. Courtesy N. Houssin, Plagemen lab, Ohio State University, Columbus, USA. Raw widefield and THUNDER image of transversal mouse adult fiber lens section. Courtesy N. Houssin, Plagemen lab, Ohio State University, Columbus, USA.](/fileadmin/_processed_/3/0/csm_Transversal_mouse_adult_fiber_lens_section_Widefield_THUNDER_teaser_6f95700ba0.jpg)
Studying Ocular Birth Defects
This article discusses how lens formation and ocular birth defects can be studied with sharp widefield microscopy images which are acquired rapidly. The mouse ocular lens is used as a model to study…
Loading...
![Two-color caspase assay with tile scan. U2OS cells were treated with the nuclear marker DRAQ5 (magenta) and CellEvent™ (yellow). Two-color caspase assay with tile scan. U2OS cells were treated with the nuclear marker DRAQ5 (magenta) and CellEvent™ (yellow).](/fileadmin/_processed_/d/e/csm_Two-color_caspase_assay_with_tile_scan_98afaa278e.jpg)
Following Multiple Events during Staurosporine Apoptosis
Coming next on MicaCam - Livestream on 19th October 2022 - In this episode of MicaCam, we show how adding additional markers to an apoptosis kit can markedly increase the amount of information a…
Loading...
![Automated Laser Microdissection for Proteome Analysis Automated Laser Microdissection for Proteome Analysis](/fileadmin/_processed_/9/6/csm_lmd-article-precise_0a4ed2da36.jpg)
Precise Spatial Proteomic Information in Tissues
Despite the availability of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance…
Loading...
![Image of murine-brain tissue showing a region removed with UV laser microdissection. Image of murine-brain tissue showing a region removed with UV laser microdissection.](/fileadmin/_processed_/a/4/csm_Murine-brain_tissue_showing_a_region_removed_with_UV_LMD_e02d1597b3.jpg)
RNA Quality after Different Tissue Sample Preparation
The influence of sample preparation and ultraviolet (UV) laser microdissection (UV LMD) on the quality of RNA from murine-brain tissue cryo-sections is described in this article. To obtain good…