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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![Urethra and phalloplasty anastomosis Clinical case: radial forearm free flap preparation with prelaminated urethra and phalloplasty anastomosis](/fileadmin/_processed_/b/e/csm_Urethra_and_phalloplasty_anastomosis_0b94d56aa8.jpg)
Using GLOW800 AR in Radial Forearm Flap Free Phalloplasty
In this video, Chief Microsurgeon Professor Küntscher and his team perform a radial forearm free flap phalloplasty and use ICG fluorescence imaging to show the blood flow in the whole flap from the…
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![Raw widefield and THUNDER image of a mouse dorsal root ganglion with tdTomato (red) expressed in the sensory neurons. Raw widefield and THUNDER image of a mouse dorsal root ganglion with tdTomato (red) expressed in the sensory neurons.](/fileadmin/_processed_/4/3/csm_Mouse_dorsal_root_ganglion_sensory_neurons_THUNDER_teaser_86235c43e7.jpg)
Fast, High-contrast 3D Imaging of Sensory Neurons
This article discusses how fast, high-contrast 3D imaging of dorsal root ganglion (DRG) tissue with a THUNDER Imager Tissue using large volume computational clearing (LVCC) allows sensory neurons to…
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![Identification of distinct structures_roundworm_Ascaris_female Identification of distinct structures_roundworm_Ascaris_female](/fileadmin/_processed_/a/b/csm_Identification_of_distinct_structures_roundworm_Ascaris_female_e4b7a4d72d.jpg)
Find Relevant Specimen Details from Overviews
Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
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![Image of fixed U2OS cell expressing mEmerald-Tomm20 denoised using a 3D RCAN model trained with matching low and high SNR image pairs acquired on an iSIM system. Image of fixed U2OS cell expressing mEmerald-Tomm20 denoised using a 3D RCAN model trained with matching low and high SNR image pairs acquired on an iSIM system.](/fileadmin/_processed_/8/7/csm_Fixed_U2OS_cell_expressing_mEmerald-Tomm20_Teaser_01c47585d7.jpg)
AI Microscopy Image Analysis – An Introduction
Artificial intelligence-guided microscopy image analysis and visualization is a powerful tool for data-driven scientific discovery. AI can help researchers tackle challenging imaging applications,…
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![Correlation of markers in the LM and the FIB image. Correlation of markers in the LM and the FIB image.](/fileadmin/_processed_/7/f/csm_Correlation_of_markers_in_the_LM_and_the_FIB_image_teaser_33ce8a2e69.jpg)
How to Target Fluorescent Structures in 3D for Cryo-FIB Milling
This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in…
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![HeLa cells. Cells kindly provided by I. Zagoriy, Mahamid Group, EMBL Heidelberg HeLa cells labeled with dark blue – Hoechst, Nuclei; magenta – MitoTracker Green, Mitochondria; turquoise - Bodipy, lipid droplets. Cells kindly provided by Ievgeniia Zagoriy, Mahamid Group, EMBL Heidelberg, Germany.](/fileadmin/_processed_/c/6/csm_LNG-non-LNGHeLa-cells_18524c7b12.jpg)
Precise 3D Targeting for EM Imaging - Access What Matters
Find out how the seamless cryo-electron tomography workflow Coral Cryo uses confocal super resolution to target your structure of interest more precisely.
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![Multi-color SRS image of tri-cellular cancer spheroid showing total lipids (yellow, 2850 cm-1), unsaturated lipids (magenta, 3050 cm-1), collagen (SHG, cyan). Sample courtesy of R. Rudolf, J Klicks, Hochschule Mannheim Multi-color SRS image of a tri-cellular cancer spheroid](/fileadmin/_processed_/9/3/csm_Tricellular_Cancer_Model_bf9916586d.jpg)
The Potential of Coherent Raman Scattering Microscopy at a Glance
Coherent Raman scattering microscopy (CRS) is a powerful approach for label-free, chemically specific imaging. It is based on the characteristic intrinsic vibrational contrast of molecules in the…
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![phalloplasty and subcutaneous mastectomy phalloplasty and subcutaneous mastectomy](/fileadmin/_processed_/f/8/csm_Phalloplasty_and_subcutaneous_mastectomy_a9c48db6ac.jpg)
How AR Surgery Benefits Radial Forearm Free Flap Phalloplasty
The goal of penile reconstruction is to provide an aesthetic penoid with tactile and erogenous sensation, so the patient can have sexual intercourse and void standing.1 Currently, the radial forearm…
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![U2OS cells labelled with SiR Actin, TMRE, CellEvent™, and DAPI U2OS cells labelled with SiR Actin, TMRE, CellEvent™, and DAPI; 13-hour time-lapse imaging; apoptosis-inducer staurosporine](/fileadmin/_processed_/e/2/csm_U2OS_cells_with_apoptosis_inducer_added_f56466a362.jpg)
Simplifying Complex Fluorescence Multiwell Plate Assays
Apoptosis, or programmed cell death, occurs during organism embryo development to eliminate unwanted cells and during healing in adults to rid the body of damaged cells and help prevent cancer.…