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Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Step by Step Guide for FRAP Experiments

Fluorescence Recovery After Photobleaching (FRAP) has been considered the most widely applied method for observing translational diffusion processes of macromolecules. The resulting information can be…
Forensics microscopy

Every Clue Counts – Forensics Inconceivable Without Microscopy

There is no crime without clues. They may be obvious, like a cartridge case at the scene of the crime or clear signs of crowbar damage on a door. But sometimes, clues are microscopically small.…

Perusing Alternatives for Automated Staining of TEM Thin Sections

Contrast in transmission electron microscopy (TEM) is mainly produced by electron scattering at the specimen: Structures that strongly scatter electrons are referred to as electron dense and appear as…
Eukaryotic cells

Widefield Calcium Imaging with Calcium Indicator Fura2

In eukaryotic cells Ca2+ is one of the most widespread second messengers used in signal transduction pathways. Intracellular levels of Ca2+ are usually kept low, as Ca2+ often forms insoluble…
Blood cells. Critical Point Drying.

Brief Introduction to Critical Point Drying

One of the uses of the Scanning Electron Microscope (SEM) is in the study of surface morphology in biological applications which requires the preservation of the surface details of a specimen. Samples…
QTM B, 1963, the first commercial automated image analysis system for microscope images, based on a TV camera and developed by Metals Research in Cambridge, England.

50 Years of Image Analysis

Modern image analysis systems perform highly sophisticated image processing functions on images from an automated microscope and digital camera. 50 years ago, the first image analysis system was…

Stem Cells in the Aging Process – the Signal Protein p53 as "Guardian of the Genome"

The physiological process of aging is an elementary part of life. The processes responsible for the aging process and the effect they have is one of the key focuses of biomedical research. Dr. Yvonne…
John B. Gurdon

Nobel Prize 2012 in Physiology or Medicine for Stem Cell Research

The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings…
Center a fluorescence bulb.

Video Tutorial: How to Align the Bulb of a Fluorescence Lamp Housing

The traditional light source for fluorescence excitation is a fluorescence lamp housing with mercury burner. A prerequisite for achieving bright and homogeneous excitation is the correct centering and…
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