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Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
Adult human Alzheimer’s brain demonstrating a panel of 15 markers.

The Shape of the Brain: Spatial Biology of Alzheimer’s Disease

Uncover cell identity and brain structure in Alzheimer's disease with Cell DIVE multiplexed imaging, demonstrating how spatial biology can lead to advances in therapy development for…
Co-detection of 10 extracellular matrix proteins and 3 topographical tissue landmarks by multiplex immunostaining within a single high-grade fibrous hotspot from a human hepatocellular carcinoma

In Situ Identification of Cancer Stem Cell Niches in Hepatocellular Carcinoma

Discover how multiplexed imaging technology uncovers cancer stem cell niches in Hepatocellular Carcinoma using multiplex immunodetection, revealing extracellular matrix dynamics. Explore precise…
Esophageal tissue with a squamous cell carcinoma labelled with the 4 biomarkers PanCk, DAPI, NaKATPase, and Vimentin.

Discover how Multiplexed Bioimaging can Advance Cancer Research

Explore multiplexing with up to 60 biomarkers, enabling advanced tumor imaging approaches to gather precise, spatially-resolved single-cell data that helps enhance cancer research and clinical…
Pancreatic Ductal Adenocarcinoma with 11 Apoptosis biomarkers shown – BAK, BAX, BCL2, BCLXL, Caspase9, CIAP1, NaKATPase, PCK26, SMAC, Vimentin, and XIAP.

Multiplexing with Luke Gammon: Advance your Spatial Biology Research

Learn how multiplexing imaging and spatial biology can help researchers better understand complex biological systems. In this interview, Dr. Gammon and Dr. Pointu of Leica Microsystems discuss pain…
Multi-tissue array with 4 markers shown including DAPI, NaKATPase, PanCk, and Vimentin.

Spatial Biology: Learning the Landscape

Spatial Biology: Understanding the organization and interaction of molecules, cells, and tissues in their native spatial context
Cell counts for each biomarker were divided by total number of cells to give a percentage of biomarker positive cells out of total cells for each biomarker.

Methods to Improve Reproducibility in Spatial Biology Research

Establish reproducibility results for a Cell DIVE multiplexed imaging study in cancer research using the BAB 200 automated system from ASLS and validated antibodies from CST
PDAC Multiplexed imaging of CST panels enables an examination of immune cell components in pancreatic ductal adenocarcinoma (IPDAC) tissue on a single slide.

Characterizing tumor environment to reveal insights and spatial resolution

Antibodies from Cell Signaling Technology are validated for use with the Cell DIVE multiplexing workflow and used to probe cell lineages in the tumor microenvironment
Pancreatic Ductal Adenocarcinoma with 5 biomarkers shown – SMA, PanCK PCK26, PanCK AE1, Vimentin, and Glut1.

Dig Deeper Into the Complexities of Pancreatic Cancer with Multiplex Imaging

Cell DIVE is an iterative staining workflow for multiplexed imaging that unveils biological pathways to dig deeper into the complexities of pancreatic cancer.
How is microscopy used in spatial biology - Teaserimage

How is Microscopy Used in Spatial Biology? A Microscopy Guide

Different spatial biology methods in microscopy, such as multiplex imaging, are helping to better understand tissue landscapes. Learn more in this microscopy guide.
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