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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![Murine esophageal organoids (DAPI, Integrin26-AF 488, SOX2-AF568) imaged with the THUNDER Imager 3D Cell Culture. Courtesy of Dr. F.T. Arroso Martins, Tamere University, Finland. Murine esophageal organoids (DAPI, Integrin26-AF 488, SOX2-AF568) imaged with the THUNDER Imager 3D Cell Culture. Courtesy of Dr. F.T. Arroso Martins, Tamere University, Finland.](/fileadmin/_processed_/f/f/csm_THUNDER_Imager_3D_Cell_Culture_Murine-esophageal-organoid_LVCC_9bc587500f.jpg)
How to Get Deeper Insights into your Organoid and Spheroid Models
In this eBook, learn about key considerations for imaging 3D cultures, such as organoids and spheroids, and discover microscopy solutions to shed new insights into dynamic processes in 3D real-time
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![Fluorescence microscopy image of liver tissue where DNA in the nuclei are stained with Feulgen-pararosanilin and visualized with transmitted green light. Fluorescence microscopy image of liver tissue where DNA in the nuclei are stained with Feulgen-pararosanilin and visualized with transmitted green light.](/fileadmin/_processed_/0/6/csm_Fluorescence_microscopy_image_of_liver_tissue_449f2971ad.jpg)
Epi-Illumination Fluorescence and Reflection-Contrast Microscopy
This article discusses the development of epi-illumination and reflection contrast for fluorescence microscopy concerning life-science applications. Much was done by the Ploem research group…
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![Application example of hyperspectral imaging Application example of hyperspectral imaging](/fileadmin/_processed_/9/c/csm_TNBC_LeGO_primary_tumor_db08add779.jpg)
Potential of Multiplex Confocal Imaging for Cancer Research and Immunology
Explore the new frontiers of multi-color fluorescent imaging: from image acquisition to analysis
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![Molecular structure of the green fluorescent protein (GFP) Molecular structure of the green fluorescent protein (GFP)](/fileadmin/_processed_/a/c/csm_Fluorescent-Proteins_363bb930f2.jpg)
Introduction to Fluorescent Proteins
Overview of fluorescent proteins (FPs) from, red (RFP) to green (GFP) and blue (BFP), with a table showing their relevant spectral characteristics.
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![Multi-tissue array with 4 markers shown including DAPI, NaKATPase, PanCk, and Vimentin. Multi-tissue array with 4 markers shown including DAPI, NaKATPase, PanCk, and Vimentin.](/fileadmin/_processed_/8/b/csm_Multi-tissue_array_with_4_markers_93819abf05.jpg)
Spatial Biology: Learning the Landscape
Spatial Biology: Understanding the organization and interaction of molecules, cells, and tissues in their native spatial context
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![In vivo imaging of a mouse pial and cortical vasculature through a glass window (ROSAmT/mG::Pdgfb-CreERT2 mouse meningeal and cortical visualization following tamoxifen induction and craniotomy). Courtesy: Thomas Mathivet, PhD In vivo imaging of a mouse pial and cortical vasculature through a glass window (ROSAmT/mG::Pdgfb-CreERT2 mouse meningeal and cortical visualization following tamoxifen induction and craniotomy). Courtesy: Thomas Mathivet, PhD](/fileadmin/_processed_/6/3/csm_Mouse_pial_and_cortical_vasculature_f409d941d0.jpg)
Windows on Neurovascular Pathologies
Discover how innate immunity can sustain deleterious effects following neurovascular pathologies and the technological developments enabling longitudinal studies into these events.
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![Lifetime-based multiplexing in live cells using TauSeparation. Mammalian cells expressing LifeAct-GFP (ibidi GmbH) and labelled with MitoTracker Green. Lifetime-based multiplexing in live cells using TauSeparation. Mammalian cells expressing LifeAct-GFP (ibidi GmbH) and labelled with MitoTracker Green. Acquisition with one detector, intensity information shown in grey. The two markers can be separated using lifetime information: LifeAct-GFP (cyan), MitoTracker Green (magenta). Image acquired with STELLARIS 5.](/fileadmin/_processed_/8/7/csm_Lifetime-based_multiplexing_in_live_cells_using_TauSeparation_8fa372a6b9.jpg)
The Power of Reproducibility, Collaboration and New Imaging Technologies
In this webinar you willl learn what impacts reproducibility in microscopy, what resources and initiatives there are to improve education and rigor and reproducibility in microscopy and how…
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![AI-based workflow for fast rare event detection in living biological samples using Autonomous Microscopy powered by Aivia AI-based workflow for fast rare event detection in living biological samples using Autonomous Microscopy powered by Aivia](/fileadmin/_processed_/c/5/csm_AI-Workfow_rare-event-detection_bcd9e88450.jpg)
AI Microscopy Enables the Efficient Detection of Rare Events
Localization and selective imaging of rare events is key for the investigation of many processes in biological samples. Yet, due to time constraints and complexity, some experiments are not feasible…
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![How is microscopy used in spatial biology? A microscopy guide. How is microscopy used in spatial biology - Teaserimage](/fileadmin/_processed_/0/f/csm_spatial-biology-ebook-tease_5ac6218fa3.jpg)
How is Microscopy Used in Spatial Biology? A Microscopy Guide
Different spatial biology methods in microscopy, such as multiplex imaging, are helping to better understand tissue landscapes. Learn more in this microscopy guide.