Leica Microsystems: Leica Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Spheroid stained with Cyan: Dapi nuclear countertain; Green AF488 Involucrin; Orange AF55 Phalloidin Actin; Magenta AF647 CK14.

Notable AI-based Solutions for Phenotypic Drug Screening

Learn about notable optical microscope solutions for phenotypic drug screening using 3D-cell culture, both planning and execution, from this free, on-demand webinar.

Virtual Reality Showcase for STELLARIS Confocal Microscopy Platform

In this webinar, you will discover how to perform 10-color acquisition using a confocal microscope. The challenges of imaged-based approaches to identify skin immune cells. A new pipeline to assess…

Confocal Imaging of Immune Cells in Tissue Samples

Dual color volume rendering of Drp1 oligomers (green) and mito OM (red) in a live U2OS cell

Multicolor 4D Super Resolution Light Sheet Microscopy

The AI Microscopy Symposium offers a unique forum for discussing the latest AI-based technologies and tools in the field of microscopy and biomedical imaging. In this scientific presentation, Yuxuan…

3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors.

Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS

Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…

Understanding Motor Sequence Generation Across Spatiotemporal Scales

We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…

Elucidate cancer development on sub-cellular level by in-vivo like tumor spheroid models.

Improve 3D Cell Biology Workflow with Light Sheet Microscopy

Understanding the sub-cellular mechanisms in carcinogenesis is of crucial importance for cancer treatment. Popular cellular models comprise cancer cells grown as monolayers. But this approach…

3D glomeruli in a portion of an ECi-cleared kidney scanned by light sheet microscopy. Courtesy of Prof. Norbert Gretz, Medical Faculty Mannheim, University of Heidelberg [1].

Using Mounting Frames for Light Sheet Sample Preparation

Sample handling is an important topic in the context of Light Sheet Microscopy. The TCS SP8 DLS integrates Light Sheet technology into an inverted confocal platform and can hence make use of general…

Drosophila embryo observed from different sides. Images were acquired in the framework of the 2018 EMBO Lightsheet Course at MPI CBG in Dresden with expert support of Bruno Cossermelli Vellutini (MPI CBG), Pavel Tomancak (MPI CBG), and Emmanuel Reynaud (UCD).

Using a Rotation Device for Light Sheet Sample Mounting

The TCS SP8 DLS from Leica Microsystems is an innovative concept to integrate the Light Sheet Microscopy technology into the confocal microscope. Due to its unique optical architecture samples can be…