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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![Identification of distinct structures_roundworm_Ascaris_female Identification of distinct structures_roundworm_Ascaris_female](/fileadmin/_processed_/a/b/csm_Identification_of_distinct_structures_roundworm_Ascaris_female_e4b7a4d72d.jpg)
Find Relevant Specimen Details from Overviews
Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
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![Correlation of markers in the LM and the FIB image. Correlation of markers in the LM and the FIB image.](/fileadmin/_processed_/7/f/csm_Correlation_of_markers_in_the_LM_and_the_FIB_image_teaser_33ce8a2e69.jpg)
How to Target Fluorescent Structures in 3D for Cryo-FIB Milling
This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in…
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![HeLa cells. Cells kindly provided by I. Zagoriy, Mahamid Group, EMBL Heidelberg HeLa cells labeled with dark blue – Hoechst, Nuclei; magenta – MitoTracker Green, Mitochondria; turquoise - Bodipy, lipid droplets. Cells kindly provided by Ievgeniia Zagoriy, Mahamid Group, EMBL Heidelberg, Germany.](/fileadmin/_processed_/c/6/csm_LNG-non-LNGHeLa-cells_18524c7b12.jpg)
Precise 3D Targeting for EM Imaging - Access What Matters
Find out how the seamless cryo-electron tomography workflow Coral Cryo uses confocal super resolution to target your structure of interest more precisely.
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![Multi-color SRS image of tri-cellular cancer spheroid showing total lipids (yellow, 2850 cm-1), unsaturated lipids (magenta, 3050 cm-1), collagen (SHG, cyan). Sample courtesy of R. Rudolf, J Klicks, Hochschule Mannheim Multi-color SRS image of a tri-cellular cancer spheroid](/fileadmin/_processed_/9/3/csm_Tricellular_Cancer_Model_bf9916586d.jpg)
The Potential of Coherent Raman Scattering Microscopy at a Glance
Coherent Raman scattering microscopy (CRS) is a powerful approach for label-free, chemically specific imaging. It is based on the characteristic intrinsic vibrational contrast of molecules in the…
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![U2OS cells labelled with SiR Actin, TMRE, CellEvent™, and DAPI U2OS cells labelled with SiR Actin, TMRE, CellEvent™, and DAPI; 13-hour time-lapse imaging; apoptosis-inducer staurosporine](/fileadmin/_processed_/e/2/csm_U2OS_cells_with_apoptosis_inducer_added_f56466a362.jpg)
Simplifying Complex Fluorescence Multiwell Plate Assays
Apoptosis, or programmed cell death, occurs during organism embryo development to eliminate unwanted cells and during healing in adults to rid the body of damaged cells and help prevent cancer.…
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![Formation of 3D spheroids from 1000 MDCK cells Formation of 3D spheroids; Time lapse acquisition over 72 hours](/fileadmin/_processed_/7/7/csm_Formation_of_3D_spheroids_from_MX1-GFP_cells_6f5e0c8972.jpg)
Efficient Long-term Time-lapse Microscopy
When doing time-lapse microscopy experiments with spheroids, there are certain challenges which can arise. As the experiments can last for several days, prolonged sample survival must be achieved…
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![](/fileadmin/_processed_/a/7/csm_Live-cell_imaging_techniques_teaser_2c45f47b4b.jpg)
Live-Cell Imaging Techniques
The understanding of complex and/or fast cellular dynamics is an important step for exploring biological processes. Therefore, today’s life science research is increasingly focused on dynamic…
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![3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors. 3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors.](/fileadmin/_processed_/4/8/csm_Spheroid_showing_depth_coding_in_different_colors_3D_DLS_2cc9dea009.jpg)
Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…
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![Dynamic Signal Enhancement powered by Aivia: Truly simultaneous multicolor imaging of live cells (U2OS) in 3D Dynamic Signal Enhancement powered by Aivia: Truly simultaneous multicolor imaging of live cells (U2OS) in 3D](/fileadmin/_processed_/b/1/csm_How_Artificial_Intelligence_Enhances_Confocal_Imaging_teaser_b7b1cbed5e.jpg)
How Artificial Intelligence Enhances Confocal Imaging
In this article, we show how artificial intelligence (AI) can enhance your imaging experiments. Namely, how Dynamic Signal Enhancement powered by Aivia improves image quality while capturing the…