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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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How Does The Cytoskeleton Transport Molecules?
VIDEO ON DEMAND - See how 3D cysts derived from MDCK cells help scientists understand how proteins are transported and recycled in tissues and the role of the cytoskeleton in this transport.
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![Developing zebrafish (Danio rerio) embryo, from sphere stage to somite stages. Developing zebrafish (Danio rerio) embryo, from sphere stage to somite stages.](/fileadmin/_processed_/8/f/csm_Developing_Zebrafish_embryo_MicaCam_teaser_62bb968899.jpg)
Studying Early Phase Development of Zebrafish Embryos
VIDEO ON DEMAND - This second edition of MicaCam focuses on combining widefield and confocal imaging to study the early-stage development of zebrafish embryos (Danio rerio), from oocyte to…
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![U2OS cells U2OS cells stained with Hoechst for nuclei (blue), MitoTracker green (Mitochondria structure, green) and TMRE (active mitochondria, magenta) and SiR for tubulin (red). Simultaneous acquisition of four channel large area overview using Spiral scan feature using the 10x/1.20 CS2 Water MotCORR objective.](/fileadmin/_processed_/f/0/csm_U2OS_cells_four_channel_Spiral_scan_Mica_673dd1380f.jpg)
How To Get Multi Label Experiment Data With Full Spatiotemporal Correlation
VIDEO ON DEMAND - The first edition of MicaCam focuses on the special challenges of live cell experiments. Our hosts Lynne Turnbull and Oliver Schlicker use the example of studying the mitochondrial…
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![Multi-color SRS image of tri-cellular cancer spheroid showing total lipids (yellow, 2850 cm-1), unsaturated lipids (magenta, 3050 cm-1), collagen (SHG, cyan). Sample courtesy of R. Rudolf, J Klicks, Hochschule Mannheim Multi-color SRS image of a tri-cellular cancer spheroid](/fileadmin/_processed_/9/3/csm_Tricellular_Cancer_Model_bf9916586d.jpg)
The Potential of Coherent Raman Scattering Microscopy at a Glance
Coherent Raman scattering microscopy (CRS) is a powerful approach for label-free, chemically specific imaging. It is based on the characteristic intrinsic vibrational contrast of molecules in the…
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![](/fileadmin/_processed_/8/6/csm_Live_cells_incubated_with_R110-SNMe2_a09ba8414e.jpg)
A Versatile Palette of Fluorescent Probes
Researchers at the Max Planck Institute for Medical Research in Heidelberg have developed a general strategy to synthesize live-cell compatible fluorogenic probes, and the result are the new MaP (Max…
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![Dual color volume rendering of Drp1 oligomers (green) and mito OM (red) in a live U2OS cell Dual color volume rendering of Drp1 oligomers (green) and mito OM (red) in a live U2OS cell](/fileadmin/_processed_/1/2/csm_Dual_color_volume_rendering_in_a_live_U2OS_cell_64e6b2186b.jpg)
Multicolor 4D Super Resolution Light Sheet Microscopy
The AI Microscopy Symposium offers a unique forum for discussing the latest AI-based technologies and tools in the field of microscopy and biomedical imaging. In this scientific presentation, Yuxuan…
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How to Prepare your Specimen for Immunofluorescence Microscopy
Immunofluorescence (IF) is a powerful method for visualizing intracellular processes, conditions and structures. IF preparations can be analyzed by various microscopy techniques (e.g. CLSM,…
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![](/fileadmin/_processed_/a/7/csm_Live-cell_imaging_techniques_teaser_2c45f47b4b.jpg)
Live-Cell Imaging Techniques
The understanding of complex and/or fast cellular dynamics is an important step for exploring biological processes. Therefore, today’s life science research is increasingly focused on dynamic…
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![3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors. 3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors.](/fileadmin/_processed_/4/8/csm_Spheroid_showing_depth_coding_in_different_colors_3D_DLS_2cc9dea009.jpg)
Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…