Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
John B. Gurdon

Nobel Prize 2012 in Physiology or Medicine for Stem Cell Research

The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings…
CARS image of cellulose fibers. The fibers are visualized through the C–H vibrations of the polyglucan chains in cellulose.

CARS Microscopy: Imaging Characteristic Vibrational Contrast of Molecules

Coherent anti-Stokes Raman scattering (CARS) microscopy is a technique that generates images based on the vibrational signatures of molecules. This imaging methods does not require labeling, yet…
Jellyfish Aequorea Victoria

Fluorescent Proteins - From the Beginnings to the Nobel Prize

Fluorescent proteins are the fundament of recent fluorescence microscopy and its modern applications. Their discovery and consequent development was one of the most exciting innovations for life…

Super-Resolution GSDIM Microscopy

The nanoscopic technique GSDIM (ground state depletion microscopy followed by individual molecule return) provides a detailed image of the spatial arrangement of proteins and other biomolecules within…

Metallography with Color and Contrast

The examination of microstructure morphology plays a decisive role in materials science and failure analysis. There are many possibilities of visualizing the real structures of materials in the light…
An ID card which has been tampered with by counterfeiters who inserted a hologram.

Is that Document Genuine or Fake? How do They Identify Fake Documents?

This article shows how forensic experts use microscopy for analysis to identify counterfeit, fake documents, such as ID cards, passports, visas, certificates, etc. Then they know if it is genuine or…
Cochlea implant. Illustration: © MED-EL.

Cochlea Implants for Deaf and Severely Hard of Hearing

The cochlea implant (CI) replaces the function of the outer ear, the middle ear and the ­cochlea of the inner ear. Basically, it consists of an external unit comprising a microphone, speech processor,…

New Standard in Electrophysiology and Deep Tissue Imaging

The function of nerve and muscle cells relies on ionic currents flowing through ion channels. These ion channels play a major role in cell physiology. One way to investigate ion channels is to use…
SPERM HY-LITER™ staining of a sexual assault smear slide which was performed by a forensic DNA crime laboratory.

Forensic Detection of Sperm from Sexual Assault Evidence

The impact of modern scientific methods on the analysis of crime scene evidence has dramatically changed many forensic sub-specialties. Arguably one of the most dramatic examples is the impact of…
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