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Corporate Communications

Leica Microsystems entwickelt und fertigt Mikroskope und wissenschaftliche Instrumente für die Analyse von Mikro- und Nanostrukturen.

Wir bieten wissenschaftliches Forschungs- und Lehrmaterial zu den Themen der Mikroskopie an. Die Inhalte sind so gestaltet, dass sie Anfänger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrer täglichen Arbeit und ihren Experimenten unterstützen. Erkunden Sie interaktive Tutorials und Anwendungshinweise, entdecken Sie die Grundlagen der Mikroskopie ebenso wie High-End-Technologien.

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How to use a Surgical Microscope as an Operating Room Nurse

Surgical microscopes play an essential role in the modern microsurgery procedures. It provides the surgeon, assistant and operating room staff with a magnified and illuminated high-quality image of…

Clinical Symposium on OCT-guided Cornea Surgery

In this recording Prof. Mehta from Singapore National Eye Centre and Prof. Fontana from Santa Maria Nuova Hospital in Regio Emilia, Italy, share their expertise on corneal surgery. They present PK,…

Fluorescence Lifetime-based Imaging Gallery

Confocal microscopy relies on the effective excitation of fluorescence probes and the efficient collection of photons emitted from the fluorescence process. One aspect of fluorescence is the emission…

Optimizing THUNDER Platform for High-Content Slide Scanning

With rising demand for full-tissue imaging and the need for FL signal quantitation in diverse biological specimens, the limits on HC imaging technology are tested, while user trainability and…

Visualizing Protein Degradation and Aggregation in the Living Cell

Our guest speaker, Prof Dr Eric Reits, presents his work on neurodegenerative disorders. Reits’ group are experts on the subject of Huntington’s disease and work towards identifying leads for…

Towards Advanced Use of Intraoperative OCT in Cataract Surgery

In this White Paper, Dr. Rachid Tahiri shares his personal experience with the Leica EnFocus intraoperative OCT, the valuable features supporting smooth surgery and how it allows him to minimize…

How Clinical and Surgical Microscopes Support Otolaryngology

The number of ENT surgery procedures is increasing year after year. It is estimated that there will be over 21 million ENT procedures performed annually worldwide by 2022. Dr. Duane Mol is the…

Life Beyond the Pixels: Deep Learning Methods for Single Cell Analysis

Our guest speaker Prof Dr Peter Horvath presents his work on single cell-based large-scale microscopy experiments. This novel targeting approach includes the use of machine learning models and…
C. elegans Gonades - THUNDER Imager  Adult hermaphrodit, Staining: blue - DAPI (Nucleus), green - SP56 (sperms), red - RME-2 (oocyte), mangenta - PGL-1 (RNA + protein granules) Image courtesy of Prof. Dr. Christian Eckmann, Martin Luther University, Halle, Germany

Physiology Image Gallery

Physiology is about the processes and functions within a living organism. Research in physiology focuses on the activities and functions of an organism’s organs, tissues, or cells, including the…
Nematostella

Live Cell Imaging Gallery

Live cell microscopy techniques are fundamental to get a better understanding of cellular and molecular function. Today, widefield microscopy is the most common technique used to visualize cell…

Super-Resolution Microscopy Image Gallery

Due to the diffraction limit of light, traditional confocal microscopy cannot resolve structures below ~240 nm. Super-resolution microscopy techniques, such as STED, PALM or STORM or some…
Virally labeled neurons (red) and astrocytes (green) in a cortical spheroid derived from human induced pluripotent stem cells. THUNDER Model Organism Imagerwith a 2x 0.15 NA objective at 3.4x zoomwas used to produce this 425 μm Z-stack (26 positions), which is presented here as an Extended Depth of Field(EDoF)projection.

Neuroscience Images

Neuroscience commonly uses microscopy to study the nervous system’s function and understand neurodegenerative diseases.

Cell Biology Image Gallery

Cell biology studies the structure, function and behavior of cells, including cell metabolism, cell cycle, and cell signaling. Fluorescence microscopes are an integral part of a cell biologist…

Dissecting Proteomic Heterogeneity of the Tumor Microenvironment

This lecture will highlight cutting edge applications in applying laser microdissection and microscaled quantitative proteomics and phosphoproteomics to uncover exquisite intra- and inter-tumor…

How to Quantify Changes in the Metabolic Status of Single Cells

Metabolic imaging based on fluorescence lifetime provides insights into the metabolic dynamics of cells, but its use has been limited as expertise in advanced microscopy techniques was needed. Now,…

Putting Dynamic Live Cell Data into the Ultrastructural Context

With workflow Coral Life, searching for a needle in the haystack is a thing of the past. Take advantage of correlative light and electron microscopy to identify directly the right cell at the right…

AI in Microscopy Webinar

We demonstrate residual channel attention networks for restoring and enhancing volumetric time-lapse (4D) fluorescence microscopy data.
Virally labeled neurons (red) and astrocytes (green) in a cortical spheroid derived from human induced pluripotent stem cells. THUNDER Model Organism Imager with a 2x 0.15 NA objective at 3.4x zoom was used to produce this 425 µm Z-stack (26 positions), which is presented here as an Extended Depth of Field (EDoF) projection.  Images courtesy of Dr. Fikri Birey  from the Dr. Sergiu Pasca laboratory at Stanford University, 3165 Porter Dr., Palo Alto, CA

Download The Guide to Live Cell Imaging

In life science research, live cell imaging is an indispensable tool to visualize cells in a state as in vivo as possible. This E-book reviews a wide range of important considerations to take to…
3D reconstruction of an intercellular bridge in a C. elegans embryo

Download EM Workflow Solutions Booklet

This publication is a compilation of appropriate workflows for the most frequently used sample preparation methods, like Correlative Methodologies, Optogenetics & Electro-Physiology, Surface Analysis,…

Application Booklet for EM TIC 3X

Today, ion beam milling is one of the most widely-used methods for preparing samples for electron microscopy. Download this 76-pages booklet today and learn how to improve your processes.

Regulators of Actin Cytoskeletal Regulation and Cell Migration in Human NK Cells

Dr. Mace will describe new advances in our understanding of the regulation of human NK cell actin cytoskeletal remodeling in cell migration and immune synapse formation derived from confocal and…

Adding Dimensions to Multiplex Molecular Imaging

Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better understand the underlying cellular and molecular mechanisms of complex…

Understanding Motor Sequence Generation Across Spatiotemporal Scales

We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…
Root-hypocotyl junction of Arabidopsis thaliana. Image acquired with TauContrast. Sample courtesy: Dr. Melanie Krebs, COS, University of Heidelberg.

Benefits of TauContrast to Image Complex Samples

In this interview, Dr. Timo Zimmermann talks about his experience with the application of TauSense tools and their potential for the investigation of demanding samples such as thick samples or…

Fast, High-quality Vitrification with the EM ICE High Pressure Freezer

The EM ICE High Pressure Freezer was developed with a unique freezing principle and uses only a single pressurization and cooling liquid: liquified nitrogen (LN2). This design enables three major…

Advanced Visualization in ENT Surgery

ENT surgery poses unique challenges. It requires excellent visualization, both in terms of magnification and illumination. As such, choosing the right operating microscope is critical.

Advanced Visualization in Spine Surgery

There have been meaningful advances in spine surgery in recent years. Minimally Invasive Spine Surgery (MISS) techniques provide significant benefits, helping to minimize surgical trauma, improve…

How Augmented Reality is Transforming Vascular Neurosurgery

Augmented Reality is changing surgery, with new information helping to improve the precision and safety of procedures. This is especially true in vascular neurosurgery where Augmented Reality is…

Overcoming Ophthalmologic Surgery Challenges

Ophthalmology surgical procedures involving both the anterior and posterior segment can be particularly challenging. Good visualization is required to operate with precision and confidence. Prof.…

Advanced Visualization in Maxillofacial Plastic and Reconstructive Surgery

Plastic and Reconstructive Surgery is very demanding. Surgical microscopes play an important role, helping to ensure flaps are well vascularized. Dr. Christine Bach is a Plastic and Reconstructive…
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