Science Lab

Benvenuti nel portale delle conoscenze di Leica Microsystems. Troverete materiale didattico e di ricerca scientifica sul tema della microscopia. Il portale supporta i principianti, i professionisti esperti e gli scienziati nel loro lavoro quotidiano e negli esperimenti. Esplorate i tutorial interattivi e le note applicative, scoprite le basi della microscopia e le tecnologie di punta. Entrate a far parte della comunità di Science Lab e condividete la vostra esperienza.

C. elegans nematode embedded in Epon epoxy resin, contrasted with osmium tetroxide. The resin block was pretrimmed by hand. Scale bar: 500 µm.

How to Save Time and Samples by Automated Ultramicrotomy

This article describes how 3D micro-CT data of a resin-embedded electron microscopy sample can be used to trim the specimen down to a defined target plane prior to sectioning. The interactive and…

Essential Guide to Ultramicrotomy

When studying samples, to visualize their fine structure with nanometer scale resolution, most often electron microscopy is used. There are 2 types: scanning electron microscopy (SEM) which images the…

Transfection using the Uncommon Bio reprogramming system. Image acquired using the THUNDER Imager 3D Cell Culture with THUNDER Large Volume Computational Clearing (LVCC) applied. Image courtesy of Samuel East, Uncommon Bio.

Designing the Future with Novel and Scalable Stem Cell Culture

Visionary biotech start-up Uncommon Bio is tackling one of the world’s biggest health challenges: food sustainability. In this webinar, Stem Cell Scientist Samuel East shows how they make stem cell…

Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s Brain Tissue labelled with 15 antibodies targeted towards markers specific to astrocytes (GFAP, S100B), microglia (TMEM119, IBA1), and Alzheimer’s-associated markers (β-amyloid and p-Tau217).

Explore Alzheimer's Spatial Proteome with Big Data

Alzheimer's disease, a genetic and sporadic neurodegenerative condition, leads to cognitive decline in mid to late life, marked by β-amyloid plaques and tau tangles. With limited treatment options,…

Documentation of an automotive clutch friction surface with a digital microscope

Automotive Part Verification and Development according to Specifications

Automotive part verification during the development and production of parts and components by suppliers or manufacturers is important for ensuring that specifications are met. Specifications are…

3D culture of ovarian cancer cells imaged using the confocal mode of Mica.

Mica: A Game-changer for Collaborative Research at Imperial College London

This interview highlights the transformative impact of Mica at Imperial College London. Scientists explain how Mica has been a game-changer, expanding research possibilities and facilitating…

Complete camera overview of EM grid recorded with 3 channels. Inserts displaying the positions, where superresolved 3D confocal images were recorded. 3D renderings of these positions are shown in the zoomed inserts. Fluorescence channels (nuclei by Hoechst, blue; mitochondria by MitoTracker Green, green; lipid Droplets by Bodipy and Crimson Beads, red). Width of a grid square is 90 ?m, width of a grid bar is 35 ?m. Samples kindly provided by Ievgeniia Zagoriy, Mahamid-Group, EMBL Heidelberg, Germany.

From Bench to Beam: A Complete Correlative Cryo Light Microscopy Workflow

In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology…

Ricerca sul cancro

Il cancro è una malattia complessa ed eterogenea causata da cellule che hanno dei difetti nella regolazione della crescita. I cambiamenti genetici ed epigenetici in una cellula o in un gruppo di…

Organismi Modello nella Ricerca

Un organismo modello è una specie utilizzata dai ricercatori per studiare specifici processi biologici. Hanno caratteristiche genetiche simili a quelle umane e vengono normalmente impiegate in aree di…

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