STELLARIS CRS コヒーレントラマン散乱顕微鏡

Selected list of CRS Publications

For an extended list of CRS Publications, see CRS microscopy on Leica Science Lab

Self propelled Janus micromotors for pH responsive release of small molecule drug
Maric T, Atladóttir S, Thamdrup L, Ilchenko O, Ghavami M, Boisen A.
Applied Materials Today, 2022
DOI: 10.1016/j.apmt.2022.101418

Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug-cell interactions
Tipping WJ, Wilson LT, An C, Leventi AA, Wark AW, Wetherill C, Tomkinson NCO, Faulds K, Graham D
Chem Sci, 2022
DOI: 10.1039/d1sc06976d

Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement
Gangfuß A, Czech A, Hentschel A, Münchberg U, Horvath R, Töpf A, O'Heir E, Lochmüller H, Stehling F, Kiewert C, Sickmann A, Kuechler A, Kaiser FJ, Kölbel H, Christiansen J, Schara-Schmidt U, Roos A.
J Pathol, 2022
DOI: 10.1002/path.5812

Noninvasive Detection of Ischemic Vascular Damage in a Pig Model of Liver Donation After Circulatory Death
Ember KJI, Hunt F, Jamieson LE, Hallett JM, Esser H, Kendall TJ, Clutton RE, Gregson R, Faulds K, Forbes SJ, Oniscu GC, Campbell CJ.
Hepatology, 2021
DOI: 10.1002/hep.31701

Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Cadena Del Castillo CE, Hannich JT, Kaech A, Chiyoda H, Brewer J, Fukuyama M, Færgeman NJ, Riezman H, Spang A.
Nat Commun, 2021
DOI: 10.1038/s41467-021-24995-9

Multivariate analysis of hyperspectral stimulated Raman scattering microscopy images
Chitra Ragupathy I, Schweikhard V, Zumbusch A.
Journal of Raman spectroscopy, 2021
DOI: 10.1002/jrs.6184

Molecular pathophysiology of human MICU1 deficiency
Kohlschmidt N, Elbracht M, Czech A, Häusler M, Phan V, Töpf A, Huang KT, Bartok A, Eggermann K, Zippel S, Eggermann T, Freier E, Groß C, Lochmüller H, Horvath R, Hajnóczky G, Weis J, Roos A.
Neuropathol Appl Neurobiol, 2021
DOI: 10.1111/nan.12694

Lipid droplets in mammalian eggs are utilized during embryonic diapause
Arena R, Bisogno S, Gąsior Ł, Rudnicka J, Bernhardt L, Haaf T, Zacchini F, Bochenek M, Fic K, Bik E, Barańska M, Bodzoń-Kułakowska A, Suder P, Depciuch J, Gurgul A, Polański Z, Ptak GE.
Proc Natl Acad Sci U S A, 2021
DOI: 10.1073/pnas.2018362118

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T.
Nat Neurosci, 2020
DOI: 10.1038/s41593-019-0566-1

A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy
Wilson LT , Tipping WJ , Jamieson LE , Wetherill C , Henley Z , Faulds K , Graham D , Mackay SP , Tomkinson NCO .
Analyst, 2020
DOI: 10.1039/d0an00865f

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering
Saarinen J, Gütter F, Lindman M, Agopov M, Fraser-Miller SJ, Scherließ R, Jokitalo E, Santos HA, Peltonen L, Isomäki A, Strachan CJ.
Biotechnol J, 2019
DOI: 10.1002/biot.201800413

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes
Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castaño-Díez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sütterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Hoernschemeyer J, Großerüschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, Van de Berg WDJ, Lauer ME.
Nat Neurosci, 2019
DOI: 10.1038/s41593-019-0423-2

Label-free characterization of Amyloid-β-plaques and associated lipids in brain tissues using stimulated Raman scattering microscopy
V. Schweikhard, A. Baral, V. Krishnamachari, W.C. Hay, M. Fuhrmann
BioRxiv, 2019
DOI: 10.1101/789248

Label free noninvasive spatially resolved NaCl concentration measurements using Coherent Anti-Stokes Raman Scattering microscopy applied to butter
Jensen BB, Glover ZJ, Pedersen SMM, Andersen U, Duelund L, Brewer JR.
Food Chem, 2019
DOI: 10.1016/j.foodchem.2019.05.155

Variability in responses observed in human white adipose tissue models
Abbott RD, Borowsky FE, Alonzo CA, Zieba A, Georgakoudi I, Kaplan DL.
J Tissue Eng Regen Med, 2018
DOI: 10.1002/term.2572

Chemical imaging of protein hydrogels undergoing alkaline dissolution by CARS microscopy
Xu B, Chen XD, Mercadé-Prieto R.
Food Chem, 2018
DOI: 10.1016/j.foodchem.2018.01.056

Label-free identification of myopathological features with coherent anti-Stokes Raman scattering
Niedieker D, GrosserÜschkamp F, Schreiner A, Barkovits K, Kötting C, Marcus K, Gerwert K, Vorgerd M.
Muscle Nerve, 2018
DOI: 10.1002/mus.26140

Understanding Dissolution and Crystallization with Imaging: A Surface Point of View
Novakovic D, Isomäki A, Pleunis B, Fraser-Miller SJ, Peltonen L, Laaksonen T, Strachan CJ.
Mol Pharm, 2018
DOI: 10.1021/acs.molpharmaceut.8b00840

Preparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methods
Ojarinta R, Saarinen J, Strachan CJ, Korhonen O, Laitinen R.
Eur J Pharm Biopharm, 2018
DOI: 10.1016/j.ejpb.2018.09.013

Chemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopy
Ebersbach P, Stehle F, Kayser O, Freier E.
BMC Plant Biol, 2018
DOI: 10.1186/s12870-018-1481-4

Ostreococcus tauri is a high-lipid content green algae that extrudes clustered lipid droplets
Smallwood CR, Chrisler W, Chen JH, Patello E, Thomas M, Boudreau R, Ekman A, Wang H, McDermott G, Evans JE
BioRxiv, 2018
DOI: 10.1101/249052

Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy
Petersen D, Mavarani L, Niedieker D, Freier E, Tannapfel A, Kötting C, Gerwert K, El-Mashtoly SF.
Analyst, 2017
DOI: 10.1039/c6an02072k

Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan
Cavalheiro RP, Lima MA, Jarrouge-Bouças TR, Viana GM, Lopes CC, Coulson-Thomas VJ, Dreyfuss JL, Yates EA, Tersariol ILS, Nader HB.
Matrix Biol, 2017
DOI: 10.1016/j.matbio.2016.12.006

Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy
Saarinen J, Sözeri E, Fraser-Miller SJ, Peltonen L, Santos HA, Isomäki A, Strachan CJ.
Int J Pharm, 2017
DOI: 10.1016/j.ijpharm.2017.03.015

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage
Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.
Nat Commun, 2017
DOI: 10.1038/ncomms14858

Noninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral Imaging
Yosef HK, Krauß SD, Lechtonen T, Jütte H, Tannapfel A, Käfferlein HU, Brüning T, Roghmann F, Noldus J, Mosig A, El-Mashtoly SF, Gerwert K.
Anal Chem, 2017
DOI: 10.1021/acs.analchem.7b01403

Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma
Thorsted B, Bloksgaard M, Groza A, Schousboe LP, Færgeman NJ, Sørensen JA, Svane-Knudsen V, Brewer JR.
Ann Otol Rhinol Laryngol, 2016
DOI: 10.1177/0003489416642784

Label-free in situ imaging of oil body dynamics and chemistry in germination
Waschatko G, Billecke N, Schwendy S, Jaurich H, Bonn M, Vilgis TA, Parekh SH.
J R Soc Interface, 2016
DOI: 10.1098/rsif.2016.0677

Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy
Zou J, Isomäki A, Hirvonen T, Aarnisalo A, Jero J, Pyykkö I.
J Otol, 2016
DOI: 10.1016/j.joto.2016.09.001

Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy
Christophersen PC, Birch D, Saarinen J, Isomäki A, Nielsen HM, Yang M, Strachan CJ, Mu H.
J Control Release, 2015
DOI: 10.1016/j.jconrel.2014.10.023

Colocalization of fluorescence and Raman microscopic images for the identification of subcellular compartments: a validation study
Krauß SD, Petersen D, Niedieker D, Fricke I, Freier E, El-Mashtoly SF, Gerwert K, Mosig A.
Analyst, 2015
DOI: 10.1039/c4an02153c

Microscopic and spectroscopic techniques to investigate lipid droplet formation and turnover in yeast
Wolinski H, Kohlwein SD.
Methods Mol Biol, 2015
DOI: 10.1007/978-1-4939-2309-0_21

Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells
Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, Haemmerle G, Breinbauer R, Zechner R, Lass A, Zimmermann R.
Biochim Biophys Acta, 2015
DOI: 10.1016/j.bbalip.2015.02.017

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells
Astanina K, Koch M, Jüngst C, Zumbusch A, Kiemer AK.
Sci Rep, 2015
DOI: 10.1038/srep11453

Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast
Wolinski H, Hofbauer HF, Hellauer K, Cristobal-Sarramian A, Kolb D, Radulovic M, Knittelfelder OL, Rechberger GN, Kohlwein SD.
Biochim Biophys Acta, 2015
DOI: 10.1016/j.bbalip.2015.08.003

Perilipin-related protein regulates lipid metabolism in C. elegans
Chughtai AA, Kaššák F, Kostrouchová M, Novotný JP, Krause MW, Saudek V, Kostrouch Z, Kostrouchová M.
PeerJ, 2015
DOI: 10.7717/peerj.1213

Fully automated registration of vibrational microspectroscopic images in histologically stained tissue sections
Yang C, Niedieker D, Grosserüschkamp F, Horn M, Tannapfel A, Kallenbach-Thieltges A, Gerwert K, Mosig A.
BMC Bioinformatics, 2015
DOI: 10.1186/s12859-015-0804-9

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae
van Zutphen T, Todde V, de Boer R, Kreim M, Hofbauer HF, Wolinski H, Veenhuis M, van der Klei IJ, Kohlwein SD.
Mol Biol Cell, 2014
DOI: 10.1091/mbc.E13-08-0448

Automated identification of subcellular organelles by coherent anti-stokes Raman scattering
El-Mashtoly SF, Niedieker D, Petersen D, Krauss SD, Freier E, Maghnouj A, Mosig A, Hahn S, Kötting C, Gerwert K.
Biophys J, 2014
DOI: 10.1016/j.bpj.2014.03.025

The emergence of lipid droplets in yeast: current status and experimental approaches
Radulovic M, Knittelfelder O, Cristobal-Sarramian A, Kolb D, Wolinski H, Kohlwein SD.
Curr Genet, 2013
DOI: 10.1007/s00294-013-0407-9

Remodeling of lipid droplets during lipolysis and growth in adipocytes
Paar M, Jüngst C, Steiner NA, Magnes C, Sinner F, Kolb D, Lass A, Zimmermann R, Zumbusch A, Kohlwein SD, Wolinski H.
J Biol Chem, 2012
DOI: 10.1074/jbc.M111.316794

Quantitative imaging of lipid metabolism in yeast: from 4D analysis to high content screens of mutant libraries
Wolinski H, Bredies K, Kohlwein SD.
Methods Cell Biol, 2012
DOI: 10.1016/B978-0-12-386487-1.00016-X

Quantitative assessment of collagen fibre orientations from two-dimensional images of soft biological tissues
Schriefl AJ, Reinisch AJ, Sankaran S, Pierce DM, Holzapfel GA.
J R Soc Interface, 2012
DOI: 10.1098/rsif.2012.0339